CHRNB4
Summary: This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:118509 Ensembl IDEnsembl:ENSG00000117971 HGNC IDHGNC:HGNC:1964 PHARMGKB IDPA26496 Map Location15q25.1 |
GO terms in CHRNB4
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IEA | GO:0001508 | action potential |
BP | TAS | GO:0006811 | ion transport |
BP | IEA | GO:0006939 | smooth muscle contraction |
BP | IEA | GO:0006940 | regulation of smooth muscle contraction |
BP | IBA | GO:0007165 | signal transduction |
BP | IDA | GO:0007165 | signal transduction |
Gene expression in normal tissue: CHRNB4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CHRNB4
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1603 | Nicotine Activity on Chromaffin Cells |
wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
kegg | hsa04080 | Neuroactive ligand-receptor interaction - Homo sapiens (human) |
kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
pharmgkb | PA162355620 | Nicotine Pathway (Chromaffin Cell), Pharmacodynamics |
reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CHRNB4
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |