CHRNB4


Summary: This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in CHRNB4


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0001508 action potential
BP TAS GO:0006811 ion transport
BP IEA GO:0006939 smooth muscle contraction
BP IEA GO:0006940 regulation of smooth muscle contraction
BP IBA GO:0007165 signal transduction
BP IDA GO:0007165 signal transduction
Showing 1 to 6 of 46 rows rows per page

Gene expression in normal tissue: CHRNB4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined10Metabolism1ERK MAPK signaling1Apoptosis regulation1DNA replication1

Pathways in CHRNB4


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP1603 Nicotine Activity on Chromaffin Cells
wikipathways WP706 Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
kegg hsa04080 Neuroactive ligand-receptor interaction - Homo sapiens (human)
kegg hsa04725 Cholinergic synapse - Homo sapiens (human)
pharmgkb PA162355620 Nicotine Pathway (Chromaffin Cell), Pharmacodynamics
reactome R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
Showing 1 to 6 of 18 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD121 GMX1778 2
iGMDRD158 NSC141540 2
iGMDRD885 Compound 110 5
iGMDRD494 Neopeltolide 2
Showing 1 to 4 of 14 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CHRNB4

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​