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HMGA1

Summary: This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namehigh mobility group AT-hook 1 OMIM IDMIM:600701 Ensembl IDEnsembl:ENSG00000137309 HGNC IDHGNC:HGNC:5010 PHARMGKB IDPA35094 Map Location6p21.31

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX TRANSCRIPTION FACTOR BINDING DNA REPAIR

GO terms in HMGA1

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	ISA	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	ISM	GO:0000981	RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF	IDA	GO:0001158	enhancer sequence-specific DNA binding
MF	ISS	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding
MF	TAS	GO:0003677	DNA binding
MF	IDA	GO:0003680	AT DNA binding

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Gene expression in normal tissue: HMGA1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HMGA1

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Database	Pathway ID	Pathway Des.
wikipathways	WP2003	miR-targeted genes in leukocytes - TarBase
wikipathways	WP2004	miR-targeted genes in lymphocytes - TarBase
wikipathways	WP2005	miR-targeted genes in muscle cell - TarBase
wikipathways	WP2006	miR-targeted genes in squamous cell - TarBase
wikipathways	WP236	Adipogenesis
wikipathways	WP3527	Preimplantation Embryo

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD137	Indisulam	3
iGMDRD427	ABT737	3
iGMDRD297	Austocystin D	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HMGA1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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