EPS15
Summary: This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| epidermal growth factor receptor pathway substrate 15 | MIM:600051 | Ensembl:ENSG00000085832 | HGNC:HGNC:3419 | PA27838 | 1p32.3 |
GO terms in EPS15
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005905 | clathrin-coated pit |
| CC | IEA | GO:0009925 | basal plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016235 | aggresome |
| CC | IEA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0030122 | AP-2 adaptor complex |
| CC | IEA | GO:0031901 | early endosome membrane |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IEA | GO:0060170 | ciliary membrane |
| BP | IEA | GO:0001921 | positive regulation of receptor recycling |
| BP | IMP | GO:0006895 | Golgi to endosome transport |
| BP | TAS | GO:0007173 | epidermal growth factor receptor signaling pathway |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | IEA | GO:0015031 | protein transport |
| BP | TAS | GO:0016050 | vesicle organization |
| BP | IMP | GO:0019065 | receptor-mediated endocytosis of virus by host cell |
| BP | IC | GO:0032456 | endocytic recycling |
| BP | TAS | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| BP | IEA | GO:0042127 | regulation of cell proliferation |
| BP | IMP | GO:0046718 | viral entry into host cell |
| BP | IDA | GO:0048268 | clathrin coat assembly |
| BP | TAS | GO:0061024 | membrane organization |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | IDA | GO:0031593 | polyubiquitin modification-dependent protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: EPS15
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPS15
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| pid | erbb1_internalization_pathway | Internalization of ErbB1 |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | notch_pathway | Notch signaling pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-182971 | EGFR downregulation |
| reactome | R-HSA-199991 | Membrane Trafficking |
| reactome | R-HSA-5653656 | Vesicle-mediated transport |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-6807004 | Negative regulation of MET activity |
| reactome | R-HSA-8856825 | Cargo recognition for clathrin-mediated endocytosis |
| reactome | R-HSA-8856828 | Clathrin-mediated endocytosis |
| reactome | R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | ndkdynaminpathway | endocytotic role of ndk phosphins and dynamin |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD888 | Compound 44 | 6 |
| iGMDRD366 | PI-103 | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD446 | LY 2183240 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPS15
CLASSFICATION
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