EPS15

Summary: This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameepidermal growth factor receptor pathway substrate 15
OMIM IDMIM:600051
Ensembl IDEnsembl:ENSG00000085832
HGNC IDHGNC:HGNC:3419
PHARMGKB IDPA27838
Map Location1p32.3

GO terms in EPS15


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005829 cytosol
CC TAS GO:0005829 cytosol
CC IDA GO:0005886 plasma membrane
CC TAS GO:0005905 clathrin-coated pit
CC IEA GO:0009925 basal plasma membrane
CC HDA GO:0016020 membrane
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Gene expression in normal tissue: EPS15

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 31undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 15undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 5LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1

Gene-drug pathway distribution

undefined13Proteasome1Longevity regulating pathway1Mitosis1Stilbenoid, diarylheptanoid and gingerol biosynthesis1PI3K/MTOR signaling1

Pathways in EPS15


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Database
Pathway ID
Pathway Des.
kegg hsa04144 Endocytosis - Homo sapiens (human)
pid erbb1_internalization_pathway Internalization of ErbB1
pid met_pathway Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pid notch_pathway Notch signaling pathway
netpath Pathway_EGFR1 EGFR1
wikipathways WP3888 VEGFA-VEGFR2 Signaling Pathway
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD434 BMS-536924 3
iGMDRD802 4-methylfasudil 3
iGMDRD202 Curcumin 3
iGMDRD300 Tozasertib 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in EPS15

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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