SERPINB4
Summary: The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation. [provided by RefSeq, Jan 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serpin family B member 4 | MIM:600518 | Ensembl:ENSG00000206073 | HGNC:HGNC:10570 | PA35539 | 18q21.33 |
GO terms in SERPINB4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0010466 | negative regulation of peptidase activity |
| BP | IBA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | IEA | GO:0010951 | negative regulation of endopeptidase activity |
| BP | NAS | GO:0030162 | regulation of proteolysis |
| BP | IMP | GO:0042270 | protection from natural killer cell mediated cytotoxicity |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005622 | intracellular |
| CC | IEA | GO:0005737 | cytoplasm |
| MF | IPI | GO:0002020 | protease binding |
| MF | IBA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | IDA | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | NAS | GO:0004867 | serine-type endopeptidase inhibitor activity |
| MF | IPI | GO:0019899 | enzyme binding |
Gene expression in normal tissue: SERPINB4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD546 | BMS-754807 | 5 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD885 | Compound 110 | 4 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD231 | Importazole | 4 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD227 | Fatostatin A | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD882 | CIL41 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SERPINB4
CLASSFICATION
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