CTBP1
Summary: This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-terminal binding protein 1 | MIM:602618 | Ensembl:ENSG00000159692 | HGNC:HGNC:2494 | PA26995 | 4p16.3 |
GO terms in CTBP1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008022 | protein C-terminus binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0019904 | protein domain specific binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | ISS | GO:0051287 | NAD binding |
| MF | IPI | GO:0070491 | repressing transcription factor binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
| CC | ISS | GO:0017053 | transcriptional repressor complex |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0019079 | viral genome replication |
| BP | IMP | GO:0031065 | positive regulation of histone deacetylation |
| BP | IMP | GO:0035067 | negative regulation of histone acetylation |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0050872 | white fat cell differentiation |
| BP | IMP | GO:0051726 | regulation of cell cycle |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IMP | GO:0090241 | negative regulation of histone H4 acetylation |
| BP | IMP | GO:1903758 | negative regulation of transcription from RNA polymerase II promoter by histone modification |
Gene expression in normal tissue: CTBP1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTBP1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atm_pathway | ATM pathway |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | notch_pathway | Notch signaling pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Wnt | Wnt |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3651 | Pathways Affected in Adenoid Cystic Carcinoma |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-5339700 | TCF7L2 mutants don't bind CTBP |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-597592 | Post-translational protein modification |
| biocarta | ctbp1pathway | sumoylation as a mechanism to modulate ctbp-dependent gene responses |
| biocarta | wntpathway | wnt signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD307 | Manumycin A | 4 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD148 | Pifithrin-mu | 1 |
| iGMDRD889 | Compound 7d-cis | 4 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD201 | SKI II | 6 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD268 | Cerulenin | 3 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD356 | PNU-74654 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTBP1
CLASSFICATION
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