CTBP1

Summary: This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameC-terminal binding protein 1
OMIM IDMIM:602618
Ensembl IDEnsembl:ENSG00000159692
HGNC IDHGNC:HGNC:2494
PHARMGKB IDPA26995
Map Location4p16.3

GO terms in CTBP1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003700 DNA-binding transcription factor activity
MF IDA GO:0003714 transcription corepressor activity
MF IPI GO:0005515 protein binding
MF TAS GO:0008022 protein C-terminus binding
MF IPI GO:0008134 transcription factor binding
MF IDA GO:0019904 protein domain specific binding
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Gene expression in normal tissue: CTBP1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 15undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 52BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 6

Gene-drug pathway distribution

undefined20Biosynthesis of secondary metabolites1Other, kinases1Chromatin histone acetylation1Protein stability and degradation1Apoptosis regulation1

Pathways in CTBP1


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Database
Pathway ID
Pathway Des.
pid atm_pathway ATM pathway
pid betacatenin_nuc_pathway Regulation of nuclear beta catenin signaling and target gene transcription
pid hes_heypathway Notch-mediated HES/HEY network
pid notch_pathway Notch signaling pathway
pid ps1pathway Presenilin action in Notch and Wnt signaling
pid rb_1pathway Regulation of retinoblastoma protein
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD307 Manumycin A 4
iGMDRD554 CHEMBL1434137 3
iGMDRD148 Pifithrin-mu 1
iGMDRD889 Compound 7d-cis 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTBP1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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