BLK

Summary: This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameBLK proto-oncogene, Src family tyrosine kinase
OMIM IDMIM:191305
Ensembl IDEnsembl:ENSG00000136573
HGNC IDHGNC:HGNC:1057
PHARMGKB IDPA25368
Map Location8p23.1

GO terms in BLK


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
BP IBA GO:0030154 cell differentiation
BP IMP GO:0032024 positive regulation of insulin secretion
BP TAS GO:0035556 intracellular signal transduction
BP IBA GO:0038083 peptidyl-tyrosine autophosphorylation
BP IBA GO:0042127 regulation of cell proliferation
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Gene expression in normal tissue: BLK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined29PI3K/MTOR signaling1Apoptosis regulation1Protein stability and degradation1Stilbenoid, diarylheptanoid and gingerol biosynthesis1ERK MAPK signaling1DNA replication1Cell cycle1

Pathways in BLK


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Database
Pathway ID
Pathway Des.
wikipathways WP1772 Apoptosis Modulation and Signaling
wikipathways WP23 B Cell Receptor Signaling Pathway
wikipathways WP306 Focal Adhesion
wikipathways WP4105 Transcriptional regulation by RUNX1
pid alphasynuclein_pathway Alpha-synuclein signaling
pid cxcr4_pathway CXCR4-mediated signaling events
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD286 Nsc 632839 4
iGMDRD882 CIL41 3
iGMDRD353 PD0325901 2
iGMDRD886 Compound 1541A 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BLK

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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