NLK
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nemo like kinase | MIM:609476 | Ensembl:ENSG00000087095 | HGNC:HGNC:29858 | PA134914500 | 17q11.2 |
GO terms in NLK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | ISS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | ISS | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | ISS | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0042501 | serine phosphorylation of STAT protein |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| BP | IDA | GO:0050821 | protein stabilization |
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004707 | MAP kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005524 | ATP binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | ISS | GO:0042169 | SH2 domain binding |
Gene expression in normal tissue: NLK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NLK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cmyb_pathway | C-MYB transcription factor network |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | wnt_noncanonical_pathway | Noncanonical Wnt signaling pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_Wnt | Wnt |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP2858 | Ectoderm Differentiation |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP364 | IL-6 signaling pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP428 | Wnt Signaling Pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| biocarta | wntpathway | wnt signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD57 | Chloropentafluorobenzene | 2 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD451 | Serdemetan | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NLK
CLASSFICATION
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