SIK1
Summary: This gene encodes a serine/threonine protein kinase that contains a ubiquitin-associated (UBA) domain. The encoded protein is a member of the adenosine monophosphate-activated kinase (AMPK) subfamily of kinases that play a role in conserved signal transduction pathways. A mutation in this gene is associated with early infantile epileptic encephalopathy 30. [provided by RefSeq, Nov 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| salt inducible kinase 1 | MIM:605705 | Ensembl:ENSG00000142178 | HGNC:HGNC:11142 | PA164725717 | 21q22.3 |
GO terms in SIK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | ISS | GO:0000287 | magnesium ion binding |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | ISS | GO:0005524 | ATP binding |
| MF | ISS | GO:0008140 | cAMP response element binding protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0071889 | 14-3-3 protein binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0031588 | nucleotide-activated protein kinase complex |
| BP | ISS | GO:0002028 | regulation of sodium ion transport |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007049 | cell cycle |
| BP | ISS | GO:0007346 | regulation of mitotic cell cycle |
| BP | ISS | GO:0010830 | regulation of myotube differentiation |
| BP | ISS | GO:0010868 | negative regulation of triglyceride biosynthetic process |
| BP | IBA | GO:0032007 | negative regulation of TOR signaling |
| BP | ISS | GO:0032792 | negative regulation of CREB transcription factor activity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0042149 | cellular response to glucose starvation |
| BP | ISS | GO:0043153 | entrainment of circadian clock by photoperiod |
| BP | ISS | GO:0045595 | regulation of cell differentiation |
| BP | ISS | GO:0045721 | negative regulation of gluconeogenesis |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0048511 | rhythmic process |
| BP | ISS | GO:0055007 | cardiac muscle cell differentiation |
| BP | IMP | GO:2000210 | positive regulation of anoikis |
Gene expression in normal tissue: SIK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SIK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-400253 | Circadian Clock |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| pid | lkb1_pathway | LKB1 signaling events |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD427 | ABT737 | 4 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD300 | Tozasertib | 4 |
| iGMDRD263 | AACOCF3 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SIK1
CLASSFICATION
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