Summary: Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008].

activin A receptor type 1MIM:102576Ensembl:ENSG00000115170HGNC:HGNC:171PA244922q24.1

GO terms in ACVR1

Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIBAGO:0043235receptor complex
CCIEAGO:0045177apical part of cell
CCIBAGO:0048179activin receptor complex
CCIDAGO:0048179activin receptor complex
BPIMPGO:0000082G1/S transition of mitotic cell cycle
BPIEAGO:0001569branching involved in blood vessel morphogenesis
BPIEAGO:0001701in utero embryonic development
BPIEAGO:0001702gastrulation with mouth forming second
BPIEAGO:0001707mesoderm formation
BPIEAGO:0001755neural crest cell migration
BPIEAGO:0002526acute inflammatory response
BPIMPGO:0003143embryonic heart tube morphogenesis
BPISSGO:0003148outflow tract septum morphogenesis
BPISSGO:0003181atrioventricular valve morphogenesis
BPIMPGO:0003183mitral valve morphogenesis
BPISSGO:0003203endocardial cushion morphogenesis
BPISSGO:0003274endocardial cushion fusion
BPIMPGO:0003289atrial septum primum morphogenesis
BPISSGO:0003289atrial septum primum morphogenesis
BPIDAGO:0006468protein phosphorylation
BPIBAGO:0007179transforming growth factor beta receptor signaling pathway
BPIDAGO:0007179transforming growth factor beta receptor signaling pathway
BPIEAGO:0007281germ cell development
BPIEAGO:0007368determination of left/right symmetry
BPIBAGO:0007389pattern specification process
BPIBAGO:0007507heart development
BPIMPGO:0009968negative regulation of signal transduction
BPIDAGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPISSGO:0010862positive regulation of pathway-restricted SMAD protein phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPIMPGO:0030278regulation of ossification
BPIGIGO:0030335positive regulation of cell migration
BPIMPGO:0030501positive regulation of bone mineralization
BPIDAGO:0030509BMP signaling pathway
BPIDAGO:0032924activin receptor signaling pathway
BPIMPGO:0032924activin receptor signaling pathway
BPIMPGO:0032926negative regulation of activin receptor signaling pathway
BPIMPGO:0045669positive regulation of osteoblast differentiation
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0051145smooth muscle cell differentiation
BPIEAGO:0060037pharyngeal system development
BPIDAGO:0060389pathway-restricted SMAD protein phosphorylation
BPISSGO:0060412ventricular septum morphogenesis
BPIMPGO:0060923cardiac muscle cell fate commitment
BPISSGO:0061312BMP signaling pathway involved in heart development
BPIMPGO:0061445endocardial cushion cell fate commitment
BPIMPGO:0071773cellular response to BMP stimulus
BPISSGO:1905007positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
BPIDAGO:2000017positive regulation of determination of dorsal identity
BPIMPGO:2001237negative regulation of extrinsic apoptotic signaling pathway
MFIDAGO:0004672protein kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFNASGO:0004675transmembrane receptor protein serine/threonine kinase activity
MFIBAGO:0005024transforming growth factor beta-activated receptor activity
MFIBAGO:0005025transforming growth factor beta receptor activity, type I
MFIEAGO:0005025transforming growth factor beta receptor activity, type I
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
MFIBAGO:0016361activin receptor activity, type I
MFIDAGO:0016361activin receptor activity, type I
MFNASGO:0017046peptide hormone binding
MFIBAGO:0019838growth factor binding
MFIDAGO:0042803protein homodimerization activity
MFIBAGO:0046332SMAD binding
MFIDAGO:0046332SMAD binding
MFIEAGO:0046872metal ion binding
MFIBAGO:0048185activin binding
MFIDAGO:0048185activin binding
MFIDAGO:0050431transforming growth factor beta binding
MFIBAGO:0098821BMP receptor activity

Gene expression in normal tissue: ACVR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ACVR1

DatabasePathway IDPathway Des.
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04350TGF-beta signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
pidalk1pathwayALK1 signaling events
pidalk2pathwayALK2 signaling events

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD307Manumycin A2
iGMDRD512nutlin 31
iGMDRD85Ursolic acid1
iGMDRD341Triacsin c6
iGMDRD297Austocystin D3
iGMDRD887Compound 23 citrate1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ACVR1