HDAC3
Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| histone deacetylase 3 | MIM:605166 | Ensembl:ENSG00000171720 | HGNC:HGNC:4854 | PA29228 | 5q31.3 |
GO terms in HDAC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003682 | chromatin binding |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IMP | GO:0003714 | transcription corepressor activity |
| MF | IMP | GO:0004407 | histone deacetylase activity |
| MF | TAS | GO:0004407 | histone deacetylase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | TAS | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0030332 | cyclin binding |
| MF | IEA | GO:0032041 | NAD-dependent histone deacetylase activity (H3-K14 specific) |
| MF | IDA | GO:0033558 | protein deacetylase activity |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IPI | GO:0051059 | NF-kappaB binding |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0006325 | chromatin organization |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006476 | protein deacetylation |
| BP | TAS | GO:0007623 | circadian rhythm |
| BP | IMP | GO:0010832 | negative regulation of myotube differentiation |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | IDA | GO:0031647 | regulation of protein stability |
| BP | IMP | GO:0032008 | positive regulation of TOR signaling |
| BP | IDA | GO:0042307 | positive regulation of protein import into nucleus |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046329 | negative regulation of JNK cascade |
| BP | IMP | GO:0051225 | spindle assembly |
| BP | IEA | GO:0070932 | histone H3 deacetylation |
| BP | IDA | GO:0071498 | cellular response to fluid shear stress |
| CC | TAS | GO:0000118 | histone deacetylase complex |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0005876 | spindle microtubule |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
Gene expression in normal tissue: HDAC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HDAC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP3414 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| wikipathways | WP3987 | HDAC6 interactions |
| wikipathways | WP3996 | Ethanol effects on histone modifications |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| biocarta | rarrxrpathway | nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells |
| biocarta | relapathway | acetylation and deacetylation of rela in nucleus |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1368071 | NR1D1 (REV-ERBA) represses gene expression |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-193670 | p75NTR negatively regulates cell cycle via SC1 |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-2644602 | Signaling by NOTCH1 PEST Domain Mutants in Cancer |
| reactome | R-HSA-2644603 | Signaling by NOTCH1 in Cancer |
| reactome | R-HSA-2644606 | Constitutive Signaling by NOTCH1 PEST Domain Mutants |
| reactome | R-HSA-2894858 | Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer |
| reactome | R-HSA-2894862 | Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants |
| reactome | R-HSA-3214815 | HDACs deacetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-390466 | Chaperonin-mediated protein folding |
| reactome | R-HSA-390471 | Association of TriC/CCT with target proteins during biosynthesis |
| reactome | R-HSA-391251 | Protein folding |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878166 | Transcriptional regulation by RUNX2 |
| reactome | R-HSA-8940973 | RUNX2 regulates osteoblast differentiation |
| reactome | R-HSA-8941326 | RUNX2 regulates bone development |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD137 | Indisulam | 4 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD802 | 4-methylfasudil | 4 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD330 | BRD4132 | 1 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HDAC3
CLASSFICATION
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