ARTN
Summary: This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| artemin | MIM:603886 | Ensembl:ENSG00000117407 | HGNC:HGNC:727 | PA25017 | 1p34.1 |
GO terms in ARTN
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008083 | growth factor activity |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007405 | neuroblast proliferation |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IEA | GO:0007422 | peripheral nervous system development |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0050930 | induction of positive chemotaxis |
| BP | IEA | GO:0061146 | Peyer's patch morphogenesis |
| BP | IEA | GO:0097021 | lymphocyte migration into lymphoid organs |
Gene expression in normal tissue: ARTN
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ARTN
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-419037 | NCAM1 interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-8853659 | RET signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD405 | PIK-75 | 1 |
| iGMDRD486 | Tosedostat | 5 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD698 | Neratinib | 5 |
| iGMDRD289 | Parthenolide | 6 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD202 | Curcumin | 6 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD251 | ML162 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 5 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD263 | AACOCF3 | 5 |
| iGMDRD552 | AZD-1775 | 5 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD42 | Vorinostat | 5 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD781 | Sirolimus | 5 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD398 | Sepantronium | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ARTN
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