ARTN


Summary: This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
arteminMIM:603886Ensembl:ENSG00000117407HGNC:HGNC:727PA250171p34.1

GO terms in ARTN


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFTASGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
CCTASGO:0005576extracellular region
CCIEAGO:0005615extracellular space
CCIEAGO:0005622intracellular
BPTASGO:0000165MAPK cascade
BPTASGO:0007165signal transduction
BPTASGO:0007405neuroblast proliferation
BPTASGO:0007411axon guidance
BPIEAGO:0007422peripheral nervous system development
BPIEAGO:0010469regulation of signaling receptor activity
BPIEAGO:0050930induction of positive chemotaxis
BPIEAGO:0061146Peyer's patch morphogenesis
BPIEAGO:0097021lymphocyte migration into lymphoid organs

Gene expression in normal tissue: ARTN

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in ARTN


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-419037NCAM1 interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-8853659RET signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD560MK-22062
iGMDRD116CD4373
iGMDRD405PIK-751
iGMDRD486Tosedostat5
iGMDRD945ML2142
iGMDRD698Neratinib5
iGMDRD289Parthenolide6
iGMDRD481Dactolisib1
iGMDRD202Curcumin6
iGMDRD137Indisulam6
iGMDRD251ML1622
iGMDRD5Tyrphostin AG 14785
iGMDRD505Pevonedistat2
iGMDRD263AACOCF35
iGMDRD552AZD-17755
iGMDRD82Quiflapon2
iGMDRD42Vorinostat5
iGMDRD871BRD63683
iGMDRD872BRD71374
iGMDRD329Merck603
iGMDRD427ABT7372
iGMDRD144NSC953976
iGMDRD781Sirolimus5
iGMDRD201SKI II1
iGMDRD61Kinetin riboside2
iGMDRD152179324-69-71
iGMDRD782DC-45-A22
iGMDRD885Compound 1102
iGMDRD138PX 123
iGMDRD60Quinoclamine2
iGMDRD369TGX-1152
iGMDRD399Selumetinib2
iGMDRD888Compound 441
iGMDRD398Sepantronium2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ARTN

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