LYL1

Summary: This gene represents a basic helix-loop-helix transcription factor. The encoded protein may play roles in blood vessel maturation and hematopoeisis. A translocation between this locus and the T cell receptor beta locus (GeneID 6957) on chromosome 7 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Sep 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameLYL1, basic helix-loop-helix family member
OMIM IDMIM:151440
Ensembl IDEnsembl:ENSG00000104903
HGNC IDHGNC:HGNC:6734
PHARMGKB IDPA30497
Map Location19p13.13

GO terms in LYL1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
MF IBA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0003677 DNA binding
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Gene expression in normal tissue: LYL1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9

Gene-drug pathway distribution

Pathways in LYL1


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Database
Pathway ID
Pathway Des.
wikipathways WP2849 Hematopoietic Stem Cell Differentiation
wikipathways WP3640 Imatinib and Chronic Myeloid Leukemia
wikipathways WP3945 TYROBP Causal Network
kegg hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD427 ABT737 3
iGMDRD297 Austocystin D 3
iGMDRD137 Indisulam 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LYL1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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