TFR2


Summary: This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transferrin receptor 2MIM:604720Ensembl:ENSG00000106327HGNC:HGNC:11762PA364777q22.1

GO terms in TFR2


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004998transferrin receptor activity
MFNASGO:0004998transferrin receptor activity
MFIPIGO:0005515protein binding
MFIEAGO:0033570transferrin transmembrane transporter activity
MFIPIGO:0039706co-receptor binding
BPNASGO:0006826iron ion transport
BPTASGO:0006879cellular iron ion homeostasis
BPIGIGO:0006898receptor-mediated endocytosis
BPIEAGO:0006953acute-phase response
BPIMPGO:0010039response to iron ion
BPIGIGO:0033216ferric iron import
BPIGIGO:0033572transferrin transport
BPTASGO:0033572transferrin transport
BPIGIGO:0045807positive regulation of endocytosis
BPIGIGO:0045944positive regulation of transcription by RNA polymerase II
BPICGO:0055072iron ion homeostasis
BPIMPGO:0055072iron ion homeostasis
BPIGIGO:0071281cellular response to iron ion
BPIMPGO:0090277positive regulation of peptide hormone secretion
BPIGIGO:0097286iron ion import
BPIGIGO:1903319positive regulation of protein maturation
CCTASGO:0005886plasma membrane
CCIGIGO:0005887integral component of plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIGIGO:0009897external side of plasma membrane
CCIDAGO:0031410cytoplasmic vesicle
CCIDAGO:1990712HFE-transferrin receptor complex

Gene expression in normal tissue: TFR2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TFR2


DatabasePathway IDPathway Des.
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-917937Iron uptake and transport
reactomeR-HSA-917977Transferrin endocytosis and recycling
wikipathwaysWP2007Iron metabolism in placenta

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD23Gossypol3
iGMDRD268Cerulenin6
iGMDRD451Serdemetan3
iGMDRD690PRIMA-1MET6
iGMDRD60Quinoclamine3
iGMDRD577BIX012946
iGMDRD224Necrostatin-13
iGMDRD888Compound 443
iGMDRD8012,4-dideoxy-DC-45-A23
iGMDRD318PAC-16
iGMDRD294Batimastat1
iGMDRD8024-methylfasudil4
iGMDRD513BML-2591
iGMDRD247Blebbistatin6
iGMDRD375GW-4058333
iGMDRD634SCHEMBL26080415
iGMDRD380Pifithrin-alpha6
iGMDRD679Bistramide A1
iGMDRD201SKI II3
iGMDRD427ABT7372
iGMDRD889Compound 7d-cis3
iGMDRD579PF7501
iGMDRD772BRD47706
iGMDRD82Quiflapon3
iGMDRD147Prima-13
iGMDRD329Merck606
iGMDRD871BRD63682
iGMDRD213SMR0000686506
iGMDRD289Parthenolide1
iGMDRD945ML2146
iGMDRD219Bax channel blocker3
iGMDRD701NVP-AUY9223
iGMDRD607Ubistatin B6
iGMDRD148Pifithrin-mu3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TFR2

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