BTG1
Summary: This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| BTG anti-proliferation factor 1 | MIM:109580 | Ensembl:ENSG00000133639 | HGNC:HGNC:1130 | PA25450 | 12q21.33 |
GO terms in BTG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | NAS | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006479 | protein methylation |
| BP | IEA | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IBA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0008285 | negative regulation of cell proliferation |
| BP | NAS | GO:0016477 | cell migration |
| BP | NAS | GO:0030308 | negative regulation of cell growth |
| BP | IEA | GO:0043434 | response to peptide hormone |
| BP | IMP | GO:0045603 | positive regulation of endothelial cell differentiation |
| BP | IDA | GO:0045663 | positive regulation of myoblast differentiation |
| BP | NAS | GO:0045663 | positive regulation of myoblast differentiation |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IBA | GO:0045930 | negative regulation of mitotic cell cycle |
| BP | IMP | GO:2000271 | positive regulation of fibroblast apoptotic process |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IMP | GO:0005737 | cytoplasm |
| MF | NAS | GO:0003712 | transcription coregulator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | NAS | GO:0019900 | kinase binding |
Gene expression in normal tissue: BTG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in BTG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03018 | RNA degradation - Homo sapiens (human) |
| wikipathways | WP410 | Exercise-induced Circadian Regulation |
| biocarta | btg2pathway | btg family proteins and cell cycle regulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD42 | Vorinostat | 5 |
| iGMDRD137 | Indisulam | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in BTG1
CLASSFICATION
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