TRPM8
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transient receptor potential cation channel subfamily M member 8 | MIM:606678 | Ensembl:ENSG00000144481 | HGNC:HGNC:17961 | PA38270 | 2q37.1 |
GO terms in TRPM8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005262 | calcium channel activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0042803 | protein homodimerization activity |
| BP | IEA | GO:0006874 | cellular calcium ion homeostasis |
| BP | IEA | GO:0009409 | response to cold |
| BP | IEA | GO:0016048 | detection of temperature stimulus |
| BP | IEA | GO:0050955 | thermoception |
| BP | IEA | GO:0051289 | protein homotetramerization |
| BP | IEA | GO:0070207 | protein homotrimerization |
| BP | TAS | GO:0070588 | calcium ion transmembrane transport |
| CC | IEA | GO:0005789 | endoplasmic reticulum membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0045121 | membrane raft |
Gene expression in normal tissue: TRPM8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRPM8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-3295583 | TRP channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD441 | TW 37 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD513 | BML-259 | 4 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD152 | 179324-69-7 | 4 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRPM8
CLASSFICATION
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