HLF
Summary: This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:142385 Ensembl IDEnsembl:ENSG00000108924 HGNC IDHGNC:HGNC:4977 PHARMGKB IDPA29311 Map Location17q22 | |||||
GO terms in HLF
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0035914 | skeletal muscle cell differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
Gene expression in normal tissue: HLF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HLF
Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HLF
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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