NRK


Summary: The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
Nik related kinaseMIM:300791Ensembl:ENSG00000123572HGNC:HGNC:25391PA134869113Xq22.3

GO terms in NRK


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004674protein serine/threonine kinase activity
MFIEAGO:0005524ATP binding
CCIBAGO:0005737cytoplasm
BPIBAGO:0000165MAPK cascade
BPIEAGO:0000185activation of MAPKKK activity
BPIEAGO:0007256activation of JNKK activity
BPIBAGO:0007346regulation of mitotic cell cycle
BPIEAGO:0007567parturition
BPIEAGO:0008285negative regulation of cell proliferation
BPIBAGO:0023014signal transduction by protein phosphorylation
BPIBAGO:0031532actin cytoskeleton reorganization
BPIBAGO:0032147activation of protein kinase activity
BPIBAGO:0048812neuron projection morphogenesis
BPIEAGO:0060721regulation of spongiotrophoblast cell proliferation

Gene expression in normal tissue: NRK

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NRK


DatabasePathway IDPathway Des.
wikipathwaysWP3644NAD+ metabolism
pidtnfpathwayTNF receptor signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD85Ursolic acid1
iGMDRD718Pyrvinium pamoate1
iGMDRD499PDMP2
iGMDRD314Tanespimycin5
iGMDRD57Chloropentafluorobenzene3
iGMDRD679Bistramide A2
iGMDRD297Austocystin D3
iGMDRD132(-)-gallocatechin-3-O-gallate6
iGMDRD1008SR-II-138A3
iGMDRD248BRD43541
iGMDRD427ABT7376
iGMDRD779PRL-3 Inhibitor I6
iGMDRD79Gemcitabine3
iGMDRD652UNC06383
iGMDRD887Compound 23 citrate3
iGMDRD872BRD71373
iGMDRD871BRD63683
iGMDRD562Navitoclax3
iGMDRD506Fedratinib2
iGMDRD886Compound 1541A2
iGMDRD322FK 8663
iGMDRD524ISX-93
iGMDRD121GMX17783
iGMDRD202Curcumin3
iGMDRD192CIL563
iGMDRD434BMS-5369243
iGMDRD782DC-45-A23
iGMDRD379BIBR-15323
iGMDRD870BRD636103
iGMDRD231Importazole3
iGMDRD8012,4-dideoxy-DC-45-A26

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NRK

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