NRK
Summary: The mouse ortholog of this gene encodes a protein kinase required for JNK activation. The encoded protein may be involved in the induction of actin polymerization in late embryogenesis.[provided by RefSeq, Jun 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Nik related kinase | MIM:300791 | Ensembl:ENSG00000123572 | HGNC:HGNC:25391 | PA134869113 | Xq22.3 |
GO terms in NRK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IBA | GO:0005737 | cytoplasm |
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0000185 | activation of MAPKKK activity |
| BP | IEA | GO:0007256 | activation of JNKK activity |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IEA | GO:0007567 | parturition |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0031532 | actin cytoskeleton reorganization |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | IEA | GO:0060721 | regulation of spongiotrophoblast cell proliferation |
Gene expression in normal tissue: NRK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NRK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3644 | NAD+ metabolism |
| pid | tnfpathway | TNF receptor signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD718 | Pyrvinium pamoate | 1 |
| iGMDRD499 | PDMP | 2 |
| iGMDRD314 | Tanespimycin | 5 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD679 | Bistramide A | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 6 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD779 | PRL-3 Inhibitor I | 6 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD652 | UNC0638 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD192 | CIL56 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD379 | BIBR-1532 | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NRK
CLASSFICATION
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