DYRK1B


Summary: This gene encodes a member of a family of nuclear-localized protein kinases. The encoded protein participates in the regulation of the cell cycle. Expression of this gene may be altered in tumor cells, and mutations in this gene were found to cause abdominal obesity-metabolic syndrome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014].

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GO terms in DYRK1B


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005634 nucleus
BP IDA GO:0006468 protein phosphorylation
BP IEA GO:0007520 myoblast fusion
BP IEA GO:0018108 peptidyl-tyrosine phosphorylation
BP IDA GO:0045893 positive regulation of transcription, DNA-templated
BP IMP GO:0060612 adipose tissue development
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Gene expression in normal tissue: DYRK1B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DYRK1B


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Database
Pathway ID
Pathway Des.
netpath Pathway_EGFR1 EGFR1
netpath Pathway_TCR TCR
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD427 ABT737 1
iGMDRD781 Sirolimus 7
iGMDRD889 Compound 7d-cis 1
iGMDRD280 CYTOCHALASIN B 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DYRK1B

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Level
Reference ID
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Cancer
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