SP140


Summary: This gene encodes a member of the SP100 family of proteins, which are share common domains including an N-terminal homogeneously staining region domain followed by a SP100/autoimmune regulator/NucP41/P75/deformed epidermal autoregulatory factor domain, a plant homeobox zinc finger, and a bromodomain. The encoded protein is interferon-inducible and is expressed at high levels in the nuclei of leukocytes. Variants of this gene have been associated with multiple sclerosis, Crohn's disease, and chronic lymphocytic leukemia. Alternative splicing results in multiple variants. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
SP140 nuclear body proteinMIM:608602Ensembl:ENSG00000079263HGNC:HGNC:17133PA382052q37.1

GO terms in SP140


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0003677DNA binding
MFTASGO:0003700DNA-binding transcription factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0046872metal ion binding
BPIEAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006952defense response
CCIDAGO:0001650fibrillar center
CCTASGO:0005634nucleus
CCTASGO:0005635nuclear envelope
CCTASGO:0005654nucleoplasm
CCIDAGO:0005739mitochondrion
CCIEAGO:0016605PML body

Gene expression in normal tissue: SP140

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SP140


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD579PF7502
iGMDRD532Olaparib3
iGMDRD424Tamatinib1
iGMDRD427ABT7373
iGMDRD79Gemcitabine3
iGMDRD446LY 21832402
iGMDRD193Fqi13
iGMDRD297Austocystin D4
iGMDRD901ELCPK3
iGMDRD280CYTOCHALASIN B2
iGMDRD679Bistramide A2
iGMDRD945ML2142
iGMDRD154NSC237666
iGMDRD138PX 125
iGMDRD255SB2250022
iGMDRD289Parthenolide2
iGMDRD6AM-5802
iGMDRD8012,4-dideoxy-DC-45-A25
iGMDRD294Batimastat1
iGMDRD871BRD63682
iGMDRD577BIX012942
iGMDRD562Navitoclax2
iGMDRD505Pevonedistat2
iGMDRD690PRIMA-1MET2
iGMDRD246NPC262
iGMDRD64Parbendazole3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SP140

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