ATP13A5


Summary: This gene encodes a member of the P5 subfamily of P-type transport ATPases. P-type ATPases form a large superfamily of cation and lipid pumps that transport inorganic cations and other substrates across cell membranes. P5 ATPases are localized to membranes of the endoplasmic reticulum (ER) and serve many important functions including transport of cargo proteins to the Golgi, glycosylation and cell wall biosynthesis, control of protein insertion orientation, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) degradation, and sensitivity to unfolded protein response (UPR) activators. The encoded protein is organized into three cytoplasmic domains (A, P, and N) and two membrane-embedded domains (T and S). The N-domain binds ATP and serves as a built-in protein kinase, which phosphorylates the P-domain. The A-domain is an intrinsic protein phosphatase, which dephosphorylates the P-domain once during each catalytic cycle. [provided by RefSeq, Jul 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM ID
PHARMGKB IDPA134952038
Map Location3q29

GO terms in ATP13A5


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0005524 ATP binding
MF TAS GO:0019829 cation-transporting ATPase activity
MF IEA GO:0046872 metal ion binding
BP IBA GO:0006874 cellular calcium ion homeostasis
BP TAS GO:0034220 ion transmembrane transport
BP IEA GO:0070588 calcium ion transmembrane transport
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Gene expression in normal tissue: ATP13A5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined28Apoptosis regulation2Stilbenoid, diarylheptanoid and gingerol biosynthesis1Chromatin other1Cell cycle1Ferroptosis1DNA replication1IGFR signaling1Leukocyte transendothelial migration1Other, kinases1

Pathways in ATP13A5


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Database
Pathway ID
Pathway Des.
reactome R-HSA-382551 Transport of small molecules
reactome R-HSA-936837 Ion transport by P-type ATPases
reactome R-HSA-983712 Ion channel transport
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD255 SB225002 8
iGMDRD260 FQI-2 3
iGMDRD138 PX 12 4
iGMDRD318 PAC-1 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ATP13A5

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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