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PLCB2

Summary: The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namephospholipase C beta 2 OMIM IDMIM:604114 Ensembl IDEnsembl:ENSG00000137841 HGNC IDHGNC:HGNC:9055 PHARMGKB IDPA33385 Map Location15q15.1

Gene Categories:

DRUGGABLE GENOME PHOSPHOLIPASE LIPASE

GO terms in PLCB2

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Term Type	Evidence Type	GO Term ID	GO Des.
MF	IMP	GO:0004435	phosphatidylinositol phospholipase C activity
MF	TAS	GO:0004435	phosphatidylinositol phospholipase C activity
MF	TAS	GO:0004629	phospholipase C activity
MF	IEA	GO:0005509	calcium ion binding
BP	TAS	GO:0006644	phospholipid metabolic process
BP	TAS	GO:0007186	G-protein coupled receptor signaling pathway

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Gene expression in normal tissue: PLCB2

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLCB2

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Database	Pathway ID	Pathway Des.
humancyc	LIPASYN-PWY	phospholipases
humancyc	PWY-6351	D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancyc	PWY-6367	D-myo-inositol-5-phosphate metabolism
humancyc	PWY-6371	superpathway of inositol phosphate compounds
pid	alphasynuclein_pathway	Alpha-synuclein signaling
pid	ar_nongenomic_pathway	Nongenotropic Androgen signaling

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD237	ABT-751	1
iGMDRD351	GW843682X	3
iGMDRD132	(-)-gallocatechin-3-O-gallate	3
iGMDRD154	NSC23766	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLCB2

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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