PLCB2
Summary: The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phospholipase C beta 2 | MIM:604114 | Ensembl:ENSG00000137841 | HGNC:HGNC:9055 | PA33385 | 15q15.1 |
GO terms in PLCB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IMP | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | TAS | GO:0004435 | phosphatidylinositol phospholipase C activity |
| MF | TAS | GO:0004629 | phospholipase C activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| BP | TAS | GO:0006644 | phospholipid metabolic process |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | TAS | GO:0007202 | activation of phospholipase C activity |
| BP | TAS | GO:0007223 | Wnt signaling pathway, calcium modulating pathway |
| BP | IEA | GO:0016042 | lipid catabolic process |
| BP | IEA | GO:0035556 | intracellular signal transduction |
| BP | TAS | GO:0043647 | inositol phosphate metabolic process |
| BP | IEA | GO:0050913 | sensory perception of bitter taste |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: PLCB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLCB2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| humancyc | LIPASYN-PWY | phospholipases |
| humancyc | PWY-6351 | D-myo-inositol (1,4,5)-trisphosphate biosynthesis |
| humancyc | PWY-6367 | D-myo-inositol-5-phosphate metabolism |
| humancyc | PWY-6371 | superpathway of inositol phosphate compounds |
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| pid | ar_nongenomic_pathway | Nongenotropic Androgen signaling |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | endothelinpathway | Endothelins |
| pid | er_nongenomic_pathway | Plasma membrane estrogen receptor signaling |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| pid | il8cxcr2_pathway | IL8- and CXCR2-mediated signaling events |
| pid | rac1_pathway | RAC1 signaling pathway |
| pid | s1p_s1p1_pathway | S1P1 pathway |
| pid | thrombin_par1_pathway | PAR1-mediated thrombin signaling events |
| pid | thrombin_par4_pathway | PAR4-mediated thrombin signaling events |
| pid | txa2pathway | Thromboxane A2 receptor signaling |
| pharmgkb | PA152530845 | Proton Pump Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA161749006 | Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics |
| pharmgkb | PA2024 | Beta-agonist/Beta-blocker Pathway, Pharmacodynamics |
| kegg | hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
| kegg | hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04261 | Adrenergic signaling in cardiomyocytes - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04540 | Gap junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04713 | Circadian entrainment - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04723 | Retrograde endocannabinoid signaling - Homo sapiens (human) |
| kegg | hsa04724 | Glutamatergic synapse - Homo sapiens (human) |
| kegg | hsa04725 | Cholinergic synapse - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04730 | Long-term depression - Homo sapiens (human) |
| kegg | hsa04742 | Taste transduction - Homo sapiens (human) |
| kegg | hsa04750 | Inflammatory mediator regulation of TRP channels - Homo sapiens (human) |
| kegg | hsa04911 | Insulin secretion - Homo sapiens (human) |
| kegg | hsa04912 | GnRH signaling pathway - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa04916 | Melanogenesis - Homo sapiens (human) |
| kegg | hsa04918 | Thyroid hormone synthesis - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa04924 | Renin secretion - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04926 | Relaxin signaling pathway - Homo sapiens (human) |
| kegg | hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa04961 | Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human) |
| kegg | hsa04970 | Salivary secretion - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
| kegg | hsa04972 | Pancreatic secretion - Homo sapiens (human) |
| kegg | hsa04973 | Carbohydrate digestion and absorption - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP26 | Signal Transduction of S1P Receptor |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3958 | GPR40 Pathway |
| wikipathways | WP428 | Wnt Signaling Pathway |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-111885 | Opioid Signalling |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112040 | G-protein mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112043 | PLC beta mediated events |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1483249 | Inositol phosphate metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-163685 | Integration of energy metabolism |
| reactome | R-HSA-1855204 | Synthesis of IP3 and IP4 in the cytosol |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-3858494 | Beta-catenin independent WNT signaling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-397795 | G-protein beta:gamma signalling |
| reactome | R-HSA-399997 | Acetylcholine regulates insulin secretion |
| reactome | R-HSA-399997 | Acetylcholine regulates insulin secretion |
| reactome | R-HSA-400451 | Free fatty acids regulate insulin secretion |
| reactome | R-HSA-400451 | Free fatty acids regulate insulin secretion |
| reactome | R-HSA-4086398 | Ca2+ pathway |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-416476 | G alpha (q) signalling events |
| reactome | R-HSA-418217 | G beta:gamma signalling through PLC beta |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-422356 | Regulation of insulin secretion |
| reactome | R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion |
| reactome | R-HSA-434316 | Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion |
| reactome | R-HSA-451326 | Activation of kainate receptors upon glutamate binding |
| reactome | R-HSA-500657 | Presynaptic function of Kainate receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD505 | Pevonedistat | 1 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD103 | SN-38 | 4 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 4 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD107 | Valdecoxib | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD126 | Tipifarnib | 7 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD369 | TGX-115 | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD207 | Capsaicin | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLCB2
CLASSFICATION
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