PLCB2


Summary: The protein encoded by this gene is a phosphodiesterase that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate to the second messengers inositol 1,4,5-trisphosphate (IP3) and diacylglycerol. The encoded protein is activated by G proteins and has been shown to be involved in the type 2 taste receptor signal transduction pathway. In addition, nuclear factor kappa B can regulate the transcription of this gene, whose protein product is also an important regulator of platelet responses. [provided by RefSeq, Jan 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
phospholipase C beta 2MIM:604114Ensembl:ENSG00000137841HGNC:HGNC:9055PA3338515q15.1

GO terms in PLCB2


Term TypeEvidence TypeGO Term IDGO Des.
MFIMPGO:0004435phosphatidylinositol phospholipase C activity
MFTASGO:0004435phosphatidylinositol phospholipase C activity
MFTASGO:0004629phospholipase C activity
MFIEAGO:0005509calcium ion binding
BPTASGO:0006644phospholipid metabolic process
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPTASGO:0007202activation of phospholipase C activity
BPTASGO:0007223Wnt signaling pathway, calcium modulating pathway
BPIEAGO:0016042lipid catabolic process
BPIEAGO:0035556intracellular signal transduction
BPTASGO:0043647inositol phosphate metabolic process
BPIEAGO:0050913sensory perception of bitter taste
CCTASGO:0005829cytosol

Gene expression in normal tissue: PLCB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PLCB2


DatabasePathway IDPathway Des.
humancycLIPASYN-PWYphospholipases
humancycPWY-6351D-myo-inositol (1,4,5)-trisphosphate biosynthesis
humancycPWY-6367D-myo-inositol-5-phosphate metabolism
humancycPWY-6371superpathway of inositol phosphate compounds
pidalphasynuclein_pathwayAlpha-synuclein signaling
pidar_nongenomic_pathwayNongenotropic Androgen signaling
pidcxcr4_pathwayCXCR4-mediated signaling events
pidendothelinpathwayEndothelins
pider_nongenomic_pathwayPlasma membrane estrogen receptor signaling
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
pidil8cxcr2_pathwayIL8- and CXCR2-mediated signaling events
pidrac1_pathwayRAC1 signaling pathway
pids1p_s1p1_pathwayS1P1 pathway
pidthrombin_par1_pathwayPAR1-mediated thrombin signaling events
pidthrombin_par4_pathwayPAR4-mediated thrombin signaling events
pidtxa2pathwayThromboxane A2 receptor signaling
pharmgkbPA152530845Proton Pump Inhibitor Pathway, Pharmacodynamics
pharmgkbPA161749006Selective Serotonin Reuptake Inhibitor Pathway, Pharmacodynamics
pharmgkbPA2024Beta-agonist/Beta-blocker Pathway, Pharmacodynamics
kegghsa00562Inositol phosphate metabolism - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04020Calcium signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04070Phosphatidylinositol signaling system - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04270Vascular smooth muscle contraction - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa04371Apelin signaling pathway - Homo sapiens (human)
kegghsa04540Gap junction - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04720Long-term potentiation - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04724Glutamatergic synapse - Homo sapiens (human)
kegghsa04725Cholinergic synapse - Homo sapiens (human)
kegghsa04726Serotonergic synapse - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04730Long-term depression - Homo sapiens (human)
kegghsa04742Taste transduction - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04911Insulin secretion - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa04916Melanogenesis - Homo sapiens (human)
kegghsa04918Thyroid hormone synthesis - Homo sapiens (human)
kegghsa04919Thyroid hormone signaling pathway - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa04924Renin secretion - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04927Cortisol synthesis and secretion - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa04934Cushing,s syndrome - Homo sapiens (human)
kegghsa04961Endocrine and other factor-regulated calcium reabsorption - Homo sapiens (human)
kegghsa04970Salivary secretion - Homo sapiens (human)
kegghsa04971Gastric acid secretion - Homo sapiens (human)
kegghsa04972Pancreatic secretion - Homo sapiens (human)
kegghsa04973Carbohydrate digestion and absorption - Homo sapiens (human)
kegghsa05010Alzheimer,s disease - Homo sapiens (human)
kegghsa05016Huntington,s disease - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05143African trypanosomiasis - Homo sapiens (human)
kegghsa05146Amoebiasis - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2059Alzheimers Disease
wikipathwaysWP26Signal Transduction of S1P Receptor
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3958GPR40 Pathway
wikipathwaysWP428Wnt Signaling Pathway
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-111885Opioid Signalling
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112040G-protein mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-112043PLC beta mediated events
reactomeR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmission
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1483249Inositol phosphate metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-1855204Synthesis of IP3 and IP4 in the cytosol
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-3858494Beta-catenin independent WNT signaling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-397795G-protein beta:gamma signalling
reactomeR-HSA-399997Acetylcholine regulates insulin secretion
reactomeR-HSA-399997Acetylcholine regulates insulin secretion
reactomeR-HSA-400451Free fatty acids regulate insulin secretion
reactomeR-HSA-400451Free fatty acids regulate insulin secretion
reactomeR-HSA-4086398Ca2+ pathway
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-416476G alpha (q) signalling events
reactomeR-HSA-418217G beta:gamma signalling through PLC beta
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
reactomeR-HSA-434316Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion
reactomeR-HSA-451326Activation of kainate receptors upon glutamate binding
reactomeR-HSA-500657Presynaptic function of Kainate receptors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD237ABT-7511
iGMDRD351GW843682X3
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD154NSC237662
iGMDRD511CHEMBL3993792
iGMDRD177Teniposide2
iGMDRD560MK-22062
iGMDRD329Merck604
iGMDRD871BRD63683
iGMDRD286Nsc 6328393
iGMDRD367Ro 28-16753
iGMDRD82Quiflapon1
iGMDRD300Tozasertib3
iGMDRD505Pevonedistat1
iGMDRD158NSC1415401
iGMDRD137Indisulam3
iGMDRD103SN-384
iGMDRD434BMS-5369241
iGMDRD705Nakiterpiosin3
iGMDRD105Triptolide4
iGMDRD6AM-5803
iGMDRD107Valdecoxib3
iGMDRD201SKI II3
iGMDRD634SCHEMBL26080413
iGMDRD433Lexibulin2
iGMDRD126Tipifarnib7
iGMDRD781Sirolimus3
iGMDRD546BMS-7548073
iGMDRD427ABT7376
iGMDRD144NSC953973
iGMDRD562Navitoclax3
iGMDRD399Selumetinib3
iGMDRD188Piperlongumine3
iGMDRD369TGX-1152
iGMDRD294Batimastat1
iGMDRD318PAC-13
iGMDRD226ML0063
iGMDRD207Capsaicin1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLCB2

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