CARD10

Summary: The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecaspase recruitment domain family member 10
OMIM IDMIM:607209
Ensembl IDEnsembl:ENSG00000100065
HGNC IDHGNC:HGNC:16422
PHARMGKB IDPA134927444
Map Location22q13.1

GO terms in CARD10


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IPI GO:0005515 protein binding
MF NAS GO:0030159 receptor signaling complex scaffold activity
CC NAS GO:0005737 cytoplasm
CC NAS GO:0032449 CBM complex
BP IDA GO:0007250 activation of NF-kappaB-inducing kinase activity
BP ISS GO:0007250 activation of NF-kappaB-inducing kinase activity
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Gene expression in normal tissue: CARD10

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 27BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 10LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 12BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3

Gene-drug pathway distribution

undefined10Protein stability and degradation2Apoptosis regulation2Cell cycle1DNA replication1

Pathways in CARD10


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Database
Pathway ID
Pathway Des.
kegg hsa04064 NF-kappa B signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD512 nutlin 3 3
iGMDRD483 SCH-529074 3
iGMDRD701 NVP-AUY922 3
iGMDRD427 ABT737 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CARD10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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