CARD10
Summary: The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]).[supplied by OMIM, Mar 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase recruitment domain family member 10 | MIM:607209 | Ensembl:ENSG00000100065 | HGNC:HGNC:16422 | PA134927444 | 22q13.1 |
GO terms in CARD10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | NAS | GO:0030159 | receptor signaling complex scaffold activity |
| CC | NAS | GO:0005737 | cytoplasm |
| CC | NAS | GO:0032449 | CBM complex |
| BP | IDA | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
| BP | ISS | GO:0007250 | activation of NF-kappaB-inducing kinase activity |
| BP | IEA | GO:0042981 | regulation of apoptotic process |
| BP | NAS | GO:0065003 | protein-containing complex assembly |
| BP | IMP | GO:0090051 | negative regulation of cell migration involved in sprouting angiogenesis |
| BP | IMP | GO:1900182 | positive regulation of protein localization to nucleus |
Gene expression in normal tissue: CARD10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CARD10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD351 | GW843682X | 5 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 6 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD356 | PNU-74654 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CARD10
CLASSFICATION
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