MAP3K10


Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase kinase kinase 10MIM:600137Ensembl:ENSG00000130758HGNC:HGNC:6849PA3059319q13.2

GO terms in MAP3K10


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005737cytoplasm
BPIBAGO:0000165MAPK cascade
BPTASGO:0006915apoptotic process
BPTASGO:0007165signal transduction
BPIMPGO:0007224smoothened signaling pathway
BPTASGO:0007254JNK cascade
BPIEAGO:0007256activation of JNKK activity
BPIBAGO:0007257activation of JUN kinase activity
BPISSGO:0007257activation of JUN kinase activity
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIDAGO:0018107peptidyl-threonine phosphorylation
BPIBAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043433negative regulation of DNA-binding transcription factor activity
BPIMPGO:0043507positive regulation of JUN kinase activity
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0046330positive regulation of JNK cascade
BPISSGO:0046777protein autophosphorylation
MFISSGO:0003714transcription corepressor activity
MFTASGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004706JUN kinase kinase kinase activity
MFISSGO:0004706JUN kinase kinase kinase activity
MFIEAGO:0005524ATP binding
MFISSGO:0042803protein homodimerization activity
MFIPIGO:0043425bHLH transcription factor binding

Gene expression in normal tissue: MAP3K10

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAP3K10


DatabasePathway IDPathway Des.
pidp38_mkk3_6pathwayp38 MAPK signaling pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP481Insulin Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD886Compound 1541A3
iGMDRD506Fedratinib1
iGMDRD888Compound 443
iGMDRD414MST-3123
iGMDRD188Piperlongumine3
iGMDRD887Compound 23 citrate2
iGMDRD318PAC-11
iGMDRD77Itraconazole2
iGMDRD870BRD636106
iGMDRD105Triptolide1
iGMDRD289Parthenolide1
iGMDRD270Ciclosporin2
iGMDRD945ML2144
iGMDRD883CIL55A3
iGMDRD280CYTOCHALASIN B1
iGMDRD79Gemcitabine3
iGMDRD427ABT7373
iGMDRD546BMS-7548073
iGMDRD144NSC953973
iGMDRD126Tipifarnib2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K10

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