MAP3K10

Summary: The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phoshorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namemitogen-activated protein kinase kinase kinase 10
OMIM IDMIM:600137
Ensembl IDEnsembl:ENSG00000130758
HGNC IDHGNC:HGNC:6849
PHARMGKB IDPA30593
Map Location19q13.2

GO terms in MAP3K10


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005737 cytoplasm
BP IBA GO:0000165 MAPK cascade
BP TAS GO:0006915 apoptotic process
BP TAS GO:0007165 signal transduction
BP IMP GO:0007224 smoothened signaling pathway
BP TAS GO:0007254 JNK cascade
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Gene expression in normal tissue: MAP3K10

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 36BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9

Gene-drug pathway distribution

undefined14Purine metabolism1IGFR signaling1Th17 cell differentiation1Chromatin histone acetylation1Other, kinases1Apoptosis regulation1

Pathways in MAP3K10


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Database
Pathway ID
Pathway Des.
pid p38_mkk3_6pathway p38 MAPK signaling pathway
wikipathways WP3915 Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways WP481 Insulin Signaling
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD886 Compound 1541A 3
iGMDRD506 Fedratinib 1
iGMDRD888 Compound 44 3
iGMDRD414 MST-312 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAP3K10

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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