HSF1
Summary: The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock transcription factor 1 | MIM:140580 | Ensembl:ENSG00000185122 | HGNC:HGNC:5224 | PA29493 | 8q24.3 |
GO terms in HSF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0001162 | RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0031072 | heat shock protein binding |
| MF | IDA | GO:0031490 | chromatin DNA binding |
| MF | IDA | GO:0042802 | identical protein binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0043621 | protein self-association |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IDA | GO:0051879 | Hsp90 protein binding |
| MF | IDA | GO:0061770 | translation elongation factor binding |
| MF | IEA | GO:0097677 | STAT family protein binding |
| MF | IEA | GO:0098847 | sequence-specific single stranded DNA binding |
| MF | IDA | GO:1990841 | promoter-specific chromatin binding |
| CC | IDA | GO:0000776 | kinetochore |
| CC | IEA | GO:0000777 | condensed chromosome kinetochore |
| CC | IEA | GO:0000791 | euchromatin |
| CC | IEA | GO:0000792 | heterochromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016605 | PML body |
| CC | IEA | GO:0045120 | pronucleus |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0097165 | nuclear stress granule |
| CC | IDA | GO:0097431 | mitotic spindle pole |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000165 | MAPK cascade |
| BP | IEA | GO:0001892 | embryonic placenta development |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006397 | mRNA processing |
| BP | IEA | GO:0006952 | defense response |
| BP | IEA | GO:0007143 | female meiotic nuclear division |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IMP | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IDA | GO:0009299 | mRNA transcription |
| BP | IEA | GO:0010667 | negative regulation of cardiac muscle cell apoptotic process |
| BP | IEA | GO:0014823 | response to activity |
| BP | IEA | GO:0032720 | negative regulation of tumor necrosis factor production |
| BP | IEA | GO:0033574 | response to testosterone |
| BP | IBA | GO:0034605 | cellular response to heat |
| BP | IDA | GO:0034605 | cellular response to heat |
| BP | IMP | GO:0034605 | cellular response to heat |
| BP | IDA | GO:0034620 | cellular response to unfolded protein |
| BP | IDA | GO:0034622 | cellular protein-containing complex assembly |
| BP | IEA | GO:0035865 | cellular response to potassium ion |
| BP | IEA | GO:0040018 | positive regulation of multicellular organism growth |
| BP | IEA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | IEA | GO:0043280 | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IMP | GO:0043497 | regulation of protein heterodimerization activity |
| BP | IBA | GO:0043618 | regulation of transcription from RNA polymerase II promoter in response to stress |
| BP | IMP | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0051028 | mRNA transport |
| BP | IDA | GO:0051260 | protein homooligomerization |
| BP | IEA | GO:0060136 | embryonic process involved in female pregnancy |
| BP | IBA | GO:0061408 | positive regulation of transcription from RNA polymerase II promoter in response to heat stress |
| BP | IDA | GO:0061408 | positive regulation of transcription from RNA polymerase II promoter in response to heat stress |
| BP | IDA | GO:0070207 | protein homotrimerization |
| BP | IEA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IEA | GO:0071222 | cellular response to lipopolysaccharide |
| BP | IDA | GO:0071276 | cellular response to cadmium ion |
| BP | IDA | GO:0071280 | cellular response to copper ion |
| BP | IEA | GO:0071392 | cellular response to estradiol stimulus |
| BP | IDA | GO:0071480 | cellular response to gamma radiation |
| BP | IDA | GO:0072738 | cellular response to diamide |
| BP | IEA | GO:0090084 | negative regulation of inclusion body assembly |
| BP | IEA | GO:0090261 | positive regulation of inclusion body assembly |
| BP | IDA | GO:1900034 | regulation of cellular response to heat |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | IMP | GO:1900365 | positive regulation of mRNA polyadenylation |
| BP | IEA | GO:1901215 | negative regulation of neuron death |
| BP | IEA | GO:1902512 | positive regulation of apoptotic DNA fragmentation |
| BP | IDA | GO:1903936 | cellular response to sodium arsenite |
| BP | IEA | GO:1904385 | cellular response to angiotensin |
| BP | IEA | GO:1904528 | positive regulation of microtubule binding |
| BP | IEA | GO:1904843 | cellular response to nitroglycerin |
| BP | IEA | GO:1904845 | cellular response to L-glutamine |
| BP | IEA | GO:1990910 | response to hypobaric hypoxia |
| BP | IEA | GO:1990911 | response to psychosocial stress |
| BP | IMP | GO:2001033 | negative regulation of double-strand break repair via nonhomologous end joining |
Gene expression in normal tissue: HSF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSF1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p73pathway | p73 transcription factor network |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371511 | HSF1 activation |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371568 | Attenuation phase |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD190 | Nilotinib | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSF1
CLASSFICATION
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