STAT5B
Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| signal transducer and activator of transcription 5B | MIM:604260 | Ensembl:ENSG00000173757 | HGNC:HGNC:11367 | PA36186 | 17q21.2 |
GO terms in STAT5B
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISS | GO:0003682 | chromatin binding |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0035259 | glucocorticoid receptor binding |
| MF | ISS | GO:0046983 | protein dimerization activity |
| BP | ISS | GO:0000255 | allantoin metabolic process |
| BP | IEA | GO:0001553 | luteinization |
| BP | IEA | GO:0001779 | natural killer cell differentiation |
| BP | ISS | GO:0006101 | citrate metabolic process |
| BP | ISS | GO:0006103 | 2-oxoglutarate metabolic process |
| BP | ISS | GO:0006105 | succinate metabolic process |
| BP | ISS | GO:0006107 | oxaloacetate metabolic process |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | ISS | GO:0006549 | isoleucine metabolic process |
| BP | ISS | GO:0006573 | valine metabolic process |
| BP | ISS | GO:0006600 | creatine metabolic process |
| BP | ISS | GO:0006631 | fatty acid metabolic process |
| BP | TAS | GO:0007259 | JAK-STAT cascade |
| BP | IEA | GO:0007565 | female pregnancy |
| BP | IEA | GO:0007595 | lactation |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IEA | GO:0019218 | regulation of steroid metabolic process |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | ISS | GO:0019530 | taurine metabolic process |
| BP | IEA | GO:0019915 | lipid storage |
| BP | IEA | GO:0030856 | regulation of epithelial cell differentiation |
| BP | IDA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0032819 | positive regulation of natural killer cell proliferation |
| BP | IEA | GO:0032825 | positive regulation of natural killer cell differentiation |
| BP | IDA | GO:0032870 | cellular response to hormone stimulus |
| BP | IEA | GO:0033077 | T cell differentiation in thymus |
| BP | TAS | GO:0035723 | interleukin-15-mediated signaling pathway |
| BP | TAS | GO:0038110 | interleukin-2-mediated signaling pathway |
| BP | TAS | GO:0038111 | interleukin-7-mediated signaling pathway |
| BP | ISS | GO:0040014 | regulation of multicellular organism growth |
| BP | IEA | GO:0040018 | positive regulation of multicellular organism growth |
| BP | IEA | GO:0042104 | positive regulation of activated T cell proliferation |
| BP | IEA | GO:0042448 | progesterone metabolic process |
| BP | IEA | GO:0043029 | T cell homeostasis |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0045086 | positive regulation of interleukin-2 biosynthetic process |
| BP | IEA | GO:0045579 | positive regulation of B cell differentiation |
| BP | IEA | GO:0045588 | positive regulation of gamma-delta T cell differentiation |
| BP | IEA | GO:0045647 | negative regulation of erythrocyte differentiation |
| BP | IDA | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | IEA | GO:0045931 | positive regulation of mitotic cell cycle |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity |
| BP | ISS | GO:0046449 | creatinine metabolic process |
| BP | IEA | GO:0046543 | development of secondary female sexual characteristics |
| BP | IEA | GO:0046544 | development of secondary male sexual characteristics |
| BP | IEA | GO:0048541 | Peyer's patch development |
| BP | IEA | GO:0050729 | positive regulation of inflammatory response |
| BP | IDA | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway |
| BP | TAS | GO:0060397 | JAK-STAT cascade involved in growth hormone signaling pathway |
| BP | IEA | GO:0070670 | response to interleukin-4 |
| BP | ISS | GO:0071363 | cellular response to growth factor stimulus |
| BP | ISS | GO:0071364 | cellular response to epidermal growth factor stimulus |
| BP | IEA | GO:0097531 | mast cell migration |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: STAT5B
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STAT5B
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP205 | IL-7 Signaling Pathway |
| wikipathways | WP22 | IL-9 Signaling Pathway |
| wikipathways | WP2203 | Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3929 | Chemokine signaling pathway |
| wikipathways | WP3946 | White fat cell differentiation |
| wikipathways | WP395 | IL-4 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP4149 | White fat cell differentiation |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
| wikipathways | WP474 | Endochondral Ossification |
| wikipathways | WP49 | IL-2 Signaling Pathway |
| wikipathways | WP581 | EPO Receptor Signaling |
| kegg | hsa04012 | ErbB signaling pathway - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04658 | Th1 and Th2 cell differentiation - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04917 | Prolactin signaling pathway - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | cxcr4_pathway | CXCR4-mediated signaling events |
| pid | epopathway | EPO signaling pathway |
| pid | erbb4_pathway | ErbB4 signaling events |
| pid | fgf_pathway | FGF signaling pathway |
| pid | gmcsf_pathway | GMCSF-mediated signaling events |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | il2_stat5pathway | IL2 signaling events mediated by STAT5 |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | il4_2pathway | IL4-mediated signaling events |
| pid | il5_pathway | IL5-mediated signaling events |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | ptp1bpathway | Signaling events mediated by PTP1B |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pharmgkb | PA162356267 | EGFR Inhibitor Pathway, Pharmacodynamics |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL4 | IL4 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_IL6 | IL6 |
| netpath | Pathway_IL9 | IL9 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_Oncostatin_M | Oncostatin_M |
| netpath | Pathway_Prolactin | Prolactin |
| netpath | Pathway_TSLP | TSLP |
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | epopathway | epo signaling pathway |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | gleevecpathway | inhibition of cellular proliferation by gleevec |
| biocarta | il22bppathway | il22 soluble receptor signaling pathway |
| biocarta | il2pathway | il 2 signaling pathway |
| biocarta | il2rbpathway | il-2 receptor beta chain in t cell activation |
| biocarta | il3pathway | il 3 signaling pathway |
| biocarta | il7pathway | il-7 signal transduction |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | tpopathway | tpo signaling pathway |
| reactome | R-HSA-1170546 | Prolactin receptor signaling |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1266695 | Interleukin-7 signaling |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1433557 | Signaling by SCF-KIT |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-186763 | Downstream signal transduction |
| reactome | R-HSA-186797 | Signaling by PDGF |
| reactome | R-HSA-2586552 | Signaling by Leptin |
| reactome | R-HSA-2586552 | Signaling by Leptin |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-8854691 | Interleukin-20 family signaling |
| reactome | R-HSA-8983432 | Interleukin-15 signaling |
| reactome | R-HSA-8985947 | Interleukin-9 signaling |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| reactome | R-HSA-9020558 | Interleukin-2 signaling |
| reactome | R-HSA-9020958 | Interleukin-21 signaling |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
| reactome | R-HSA-982772 | Growth hormone receptor signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD42 | Vorinostat | 1 |
| iGMDRD322 | FK 866 | 2 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD705 | Nakiterpiosin | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD202 | Curcumin | 4 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD138 | PX 12 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STAT5B
CLASSFICATION
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