STAT5B


Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
signal transducer and activator of transcription 5BMIM:604260Ensembl:ENSG00000173757HGNC:HGNC:11367PA3618617q21.2

GO terms in STAT5B


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIEAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFISSGO:0003682chromatin binding
MFTASGO:0003700DNA-binding transcription factor activity
MFTASGO:0004713protein tyrosine kinase activity
MFIPIGO:0005515protein binding
MFIPIGO:0035259glucocorticoid receptor binding
MFISSGO:0046983protein dimerization activity
BPISSGO:0000255allantoin metabolic process
BPIEAGO:0001553luteinization
BPIEAGO:0001779natural killer cell differentiation
BPISSGO:0006101citrate metabolic process
BPISSGO:00061032-oxoglutarate metabolic process
BPISSGO:0006105succinate metabolic process
BPISSGO:0006107oxaloacetate metabolic process
BPTASGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006366transcription by RNA polymerase II
BPISSGO:0006549isoleucine metabolic process
BPISSGO:0006573valine metabolic process
BPISSGO:0006600creatine metabolic process
BPISSGO:0006631fatty acid metabolic process
BPTASGO:0007259JAK-STAT cascade
BPIEAGO:0007565female pregnancy
BPIEAGO:0007595lactation
BPIEAGO:0018108peptidyl-tyrosine phosphorylation
BPIEAGO:0019218regulation of steroid metabolic process
BPTASGO:0019221cytokine-mediated signaling pathway
BPISSGO:0019530taurine metabolic process
BPIEAGO:0019915lipid storage
BPIEAGO:0030856regulation of epithelial cell differentiation
BPIDAGO:0032355response to estradiol
BPIEAGO:0032819positive regulation of natural killer cell proliferation
BPIEAGO:0032825positive regulation of natural killer cell differentiation
BPIDAGO:0032870cellular response to hormone stimulus
BPIEAGO:0033077T cell differentiation in thymus
BPTASGO:0035723interleukin-15-mediated signaling pathway
BPTASGO:0038110interleukin-2-mediated signaling pathway
BPTASGO:0038111interleukin-7-mediated signaling pathway
BPISSGO:0040014regulation of multicellular organism growth
BPIEAGO:0040018positive regulation of multicellular organism growth
BPIEAGO:0042104positive regulation of activated T cell proliferation
BPIEAGO:0042448progesterone metabolic process
BPIEAGO:0043029T cell homeostasis
BPIEAGO:0043066negative regulation of apoptotic process
BPIEAGO:0045086positive regulation of interleukin-2 biosynthetic process
BPIEAGO:0045579positive regulation of B cell differentiation
BPIEAGO:0045588positive regulation of gamma-delta T cell differentiation
BPIEAGO:0045647negative regulation of erythrocyte differentiation
BPIDAGO:0045648positive regulation of erythrocyte differentiation
BPIEAGO:0045931positive regulation of mitotic cell cycle
BPISSGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0045954positive regulation of natural killer cell mediated cytotoxicity
BPISSGO:0046449creatinine metabolic process
BPIEAGO:0046543development of secondary female sexual characteristics
BPIEAGO:0046544development of secondary male sexual characteristics
BPIEAGO:0048541Peyer's patch development
BPIEAGO:0050729positive regulation of inflammatory response
BPIDAGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
BPTASGO:0060397JAK-STAT cascade involved in growth hormone signaling pathway
BPIEAGO:0070670response to interleukin-4
BPISSGO:0071363cellular response to growth factor stimulus
BPISSGO:0071364cellular response to epidermal growth factor stimulus
BPIEAGO:0097531mast cell migration
CCISSGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCISSGO:0005737cytoplasm
CCTASGO:0005829cytosol

Gene expression in normal tissue: STAT5B

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in STAT5B


DatabasePathway IDPathway Des.
wikipathwaysWP127IL-5 Signaling Pathway
wikipathwaysWP2034Leptin signaling pathway
wikipathwaysWP2037Prolactin Signaling Pathway
wikipathwaysWP205IL-7 Signaling Pathway
wikipathwaysWP22IL-9 Signaling Pathway
wikipathwaysWP2203Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway
wikipathwaysWP2324AGE-RAGE pathway
wikipathwaysWP236Adipogenesis
wikipathwaysWP2374Oncostatin M Signaling Pathway
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2593JAK-STAT
wikipathwaysWP286IL-3 Signaling Pathway
wikipathwaysWP304Kit receptor signaling pathway
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3929Chemokine signaling pathway
wikipathwaysWP3946White fat cell differentiation
wikipathwaysWP395IL-4 Signaling Pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP4149White fat cell differentiation
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP474Endochondral Ossification
wikipathwaysWP49IL-2 Signaling Pathway
wikipathwaysWP581EPO Receptor Signaling
kegghsa04012ErbB signaling pathway - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04630Jak-STAT signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05161Hepatitis B - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
kegghsa05220Chronic myeloid leukemia - Homo sapiens (human)
kegghsa05221Acute myeloid leukemia - Homo sapiens (human)
kegghsa05223Non-small cell lung cancer - Homo sapiens (human)
pidangiopoietinreceptor_pathwayAngiopoietin receptor Tie2-mediated signaling
pidcxcr4_pathwayCXCR4-mediated signaling events
pidepopathwayEPO signaling pathway
piderbb4_pathwayErbB4 signaling events
pidfgf_pathwayFGF signaling pathway
pidgmcsf_pathwayGMCSF-mediated signaling events
pidil2_1pathwayIL2-mediated signaling events
pidil2_stat5pathwayIL2 signaling events mediated by STAT5
pidil3_pathwayIL3-mediated signaling events
pidil4_2pathwayIL4-mediated signaling events
pidil5_pathwayIL5-mediated signaling events
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidptp1bpathwaySignaling events mediated by PTP1B
pidreg_gr_pathwayGlucocorticoid receptor regulatory network
pidtcptp_pathwaySignaling events mediated by TCPTP
pharmgkbPA162356267EGFR Inhibitor Pathway, Pharmacodynamics
netpathPathway_EGFR1EGFR1
netpathPathway_IL-7IL-7
netpathPathway_IL2IL2
netpathPathway_IL3IL3
netpathPathway_IL4IL4
netpathPathway_IL5IL5
netpathPathway_IL6IL6
netpathPathway_IL9IL9
netpathPathway_KitReceptorKitReceptor
netpathPathway_Oncostatin_MOncostatin_M
netpathPathway_ProlactinProlactin
netpathPathway_TSLPTSLP
biocartabiopeptidespathwaybioactive peptide induced signaling pathway
biocartaepopathwayepo signaling pathway
biocartaghpathwaygrowth hormone signaling pathway
biocartagleevecpathwayinhibition of cellular proliferation by gleevec
biocartail22bppathwayil22 soluble receptor signaling pathway
biocartail2pathwayil 2 signaling pathway
biocartail2rbpathwayil-2 receptor beta chain in t cell activation
biocartail3pathwayil 3 signaling pathway
biocartail7pathwayil-7 signal transduction
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartatpopathwaytpo signaling pathway
reactomeR-HSA-1170546Prolactin receptor signaling
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1266695Interleukin-7 signaling
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1433557Signaling by SCF-KIT
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-168256Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-1839117Signaling by cytosolic FGFR1 fusion mutants
reactomeR-HSA-1839124FGFR1 mutant receptor activation
reactomeR-HSA-186763Downstream signal transduction
reactomeR-HSA-186797Signaling by PDGF
reactomeR-HSA-2586552Signaling by Leptin
reactomeR-HSA-2586552Signaling by Leptin
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-451927Interleukin-2 family signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-512988Interleukin-3, Interleukin-5 and GM-CSF signaling
reactomeR-HSA-5655302Signaling by FGFR1 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-8854691Interleukin-20 family signaling
reactomeR-HSA-8983432Interleukin-15 signaling
reactomeR-HSA-8985947Interleukin-9 signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9020558Interleukin-2 signaling
reactomeR-HSA-9020558Interleukin-2 signaling
reactomeR-HSA-9020958Interleukin-21 signaling
reactomeR-HSA-982772Growth hormone receptor signaling
reactomeR-HSA-982772Growth hormone receptor signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD945ML2143
iGMDRD466Chaetocin2
iGMDRD679Bistramide A1
iGMDRD446LY 21832405
iGMDRD781Sirolimus2
iGMDRD427ABT7373
iGMDRD512nutlin 31
iGMDRD42Vorinostat1
iGMDRD322FK 8662
iGMDRD505Pevonedistat4
iGMDRD147Prima-11
iGMDRD506Fedratinib1
iGMDRD329Merck602
iGMDRD398Sepantronium2
iGMDRD871BRD63681
iGMDRD286Nsc 6328392
iGMDRD188Piperlongumine3
iGMDRD77Itraconazole3
iGMDRD705Nakiterpiosin1
iGMDRD105Triptolide2
iGMDRD289Parthenolide4
iGMDRD137Indisulam2
iGMDRD202Curcumin4
iGMDRD121GMX17782
iGMDRD138PX 123

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STAT5B

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