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CNTN1

Summary: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namecontactin 1 OMIM IDMIM:600016 Ensembl IDEnsembl:ENSG00000018236 HGNC IDHGNC:HGNC:2171 PHARMGKB IDPA26685 Map Location12q12

Gene Categories:

DRUGGABLE GENOME

GO terms in CNTN1

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0005886	plasma membrane
CC	TAS	GO:0016020	membrane
CC	IEA	GO:0031225	anchored component of membrane
CC	IEA	GO:0043209	myelin sheath
CC	IEA	GO:0045121	membrane raft
CC	HDA	GO:0070062	extracellular exosome

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Gene expression in normal tissue: CNTN1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CNTN1

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-1266738	Developmental Biology
reactome	R-HSA-157118	Signaling by NOTCH
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-1980143	Signaling by NOTCH1
reactome	R-HSA-1980145	Signaling by NOTCH2
reactome	R-HSA-2122948	Activated NOTCH1 Transmits Signal to the Nucleus

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD484	Pluripotin	4
iGMDRD701	NVP-AUY922	3
iGMDRD427	ABT737	3
iGMDRD512	nutlin 3	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CNTN1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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