CNTN1
Summary: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| contactin 1 | MIM:600016 | Ensembl:ENSG00000018236 | HGNC:HGNC:2171 | PA26685 | 12q12 |
Gene Categories:
DRUGGABLE GENOMEGO terms in CNTN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0016020 | membrane |
| CC | IEA | GO:0031225 | anchored component of membrane |
| CC | IEA | GO:0043209 | myelin sheath |
| CC | IEA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IEA | GO:0007219 | Notch signaling pathway |
| BP | IEA | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0010765 | positive regulation of sodium ion transport |
| BP | IEA | GO:0010976 | positive regulation of neuron projection development |
| BP | IEA | GO:0021549 | cerebellum development |
| BP | IEA | GO:0031175 | neuron projection development |
| BP | IEA | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0030246 | carbohydrate binding |
Gene expression in normal tissue: CNTN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CNTN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980145 | Signaling by NOTCH2 |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2979096 | NOTCH2 Activation and Transmission of Signal to the Nucleus |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-447043 | Neurofascin interactions |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| pid | notch_pathway | Notch signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD484 | Pluripotin | 4 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD341 | Triacsin c | 5 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD882 | CIL41 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CNTN1
CLASSFICATION
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