CNTN1


Summary: The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
contactin 1MIM:600016Ensembl:ENSG00000018236HGNC:HGNC:2171PA2668512q12

Gene Categories:

DRUGGABLE GENOME

GO terms in CNTN1


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0005886plasma membrane
CCTASGO:0016020membrane
CCIEAGO:0031225anchored component of membrane
CCIEAGO:0043209myelin sheath
CCIEAGO:0045121membrane raft
CCHDAGO:0070062extracellular exosome
BPIEAGO:0007155cell adhesion
BPIEAGO:0007219Notch signaling pathway
BPIEAGO:0010628positive regulation of gene expression
BPIEAGO:0010765positive regulation of sodium ion transport
BPIEAGO:0010976positive regulation of neuron projection development
BPIEAGO:0021549cerebellum development
BPIEAGO:0031175neuron projection development
BPIEAGO:0050731positive regulation of peptidyl-tyrosine phosphorylation
MFIPIGO:0005515protein binding
MFIEAGO:0030246carbohydrate binding

Gene expression in normal tissue: CNTN1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CNTN1


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980145Signaling by NOTCH2
reactomeR-HSA-2122948Activated NOTCH1 Transmits Signal to the Nucleus
reactomeR-HSA-2979096NOTCH2 Activation and Transmission of Signal to the Nucleus
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-447043Neurofascin interactions
kegghsa04514Cell adhesion molecules (CAMs) - Homo sapiens (human)
pidnotch_pathwayNotch signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD484Pluripotin4
iGMDRD701NVP-AUY9223
iGMDRD427ABT7373
iGMDRD512nutlin 33
iGMDRD123Isoevodiamine1
iGMDRD341Triacsin c5
iGMDRD446LY 21832404
iGMDRD77Itraconazole1
iGMDRD187BRD98763
iGMDRD705Nakiterpiosin4
iGMDRD434BMS-5369243
iGMDRD322FK 8661
iGMDRD60Quinoclamine2
iGMDRD662JQ-13
iGMDRD577BIX012942
iGMDRD100Zebularine3
iGMDRD882CIL413

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CNTN1

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