Summary: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008].

C-X-C motif chemokine receptor 1MIM:146929Ensembl:ENSG00000163464HGNC:HGNC:6026PA298422q35

GO terms in CXCR1

Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004918interleukin-8 receptor activity
MFTASGO:0004930G-protein coupled receptor activity
MFTASGO:0004950chemokine receptor activity
MFIBAGO:0016493C-C chemokine receptor activity
MFIBAGO:0019956chemokine binding
MFIBAGO:0019957C-C chemokine binding
MFIPIGO:0019959interleukin-8 binding
BPTASGO:0002407dendritic cell chemotaxis
BPIBAGO:0006955immune response
BPIDAGO:0007166cell surface receptor signaling pathway
BPTASGO:0007186G-protein coupled receptor signaling pathway
BPIBAGO:0007204positive regulation of cytosolic calcium ion concentration
BPIBAGO:0019722calcium-mediated signaling
BPIBAGO:0030593neutrophil chemotaxis
BPIDAGO:0031623receptor internalization
BPIEAGO:0038112interleukin-8-mediated signaling pathway
BPTASGO:0043312neutrophil degranulation
BPIBAGO:0060326cell chemotaxis
BPIEAGO:0070098chemokine-mediated signaling pathway
CCTASGO:0005886plasma membrane
CCIBAGO:0009897external side of plasma membrane
CCIEAGO:0016021integral component of membrane
CCTASGO:0030667secretory granule membrane

Gene expression in normal tissue: CXCR1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CXCR1

DatabasePathway IDPathway Des.
wikipathwaysWP117GPCRs, Other
wikipathwaysWP24Peptide GPCRs
wikipathwaysWP2848Differentiation Pathway
wikipathwaysWP3646Hepatitis C and Hepatocellular Carcinoma
wikipathwaysWP455GPCRs, Class A Rhodopsin-like
kegghsa04060Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegghsa04062Chemokine signaling pathway - Homo sapiens (human)
kegghsa04072Phospholipase D signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
pidil8cxcr1_pathwayIL8- and CXCR1-mediated signaling events
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-372790Signaling by GPCR
reactomeR-HSA-373076Class A/1 (Rhodopsin-like receptors)
reactomeR-HSA-375276Peptide ligand-binding receptors
reactomeR-HSA-380108Chemokine receptors bind chemokines
reactomeR-HSA-388396GPCR downstream signalling
reactomeR-HSA-418594G alpha (i) signalling events
reactomeR-HSA-500792GPCR ligand binding
reactomeR-HSA-6798695Neutrophil degranulation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD297Austocystin D3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CXCR1