CXCR1
Summary: The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| C-X-C motif chemokine receptor 1 | MIM:146929 | Ensembl:ENSG00000163464 | HGNC:HGNC:6026 | PA29842 | 2q35 |
GO terms in CXCR1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004918 | interleukin-8 receptor activity |
| MF | TAS | GO:0004930 | G-protein coupled receptor activity |
| MF | TAS | GO:0004950 | chemokine receptor activity |
| MF | IBA | GO:0016493 | C-C chemokine receptor activity |
| MF | IBA | GO:0019956 | chemokine binding |
| MF | IBA | GO:0019957 | C-C chemokine binding |
| MF | IPI | GO:0019959 | interleukin-8 binding |
| BP | TAS | GO:0002407 | dendritic cell chemotaxis |
| BP | IBA | GO:0006935 | chemotaxis |
| BP | IBA | GO:0006955 | immune response |
| BP | IDA | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007186 | G-protein coupled receptor signaling pathway |
| BP | IBA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IBA | GO:0019722 | calcium-mediated signaling |
| BP | IBA | GO:0030593 | neutrophil chemotaxis |
| BP | IDA | GO:0031623 | receptor internalization |
| BP | IEA | GO:0038112 | interleukin-8-mediated signaling pathway |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IBA | GO:0060326 | cell chemotaxis |
| BP | IEA | GO:0070098 | chemokine-mediated signaling pathway |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0009897 | external side of plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | TAS | GO:0030667 | secretory granule membrane |
Gene expression in normal tissue: CXCR1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CXCR1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP117 | GPCRs, Other |
| wikipathways | WP24 | Peptide GPCRs |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP455 | GPCRs, Class A Rhodopsin-like |
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04072 | Phospholipase D signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| pid | il8cxcr1_pathway | IL8- and CXCR1-mediated signaling events |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-373076 | Class A/1 (Rhodopsin-like receptors) |
| reactome | R-HSA-375276 | Peptide ligand-binding receptors |
| reactome | R-HSA-380108 | Chemokine receptors bind chemokines |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-500792 | GPCR ligand binding |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD137 | Indisulam | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CXCR1
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