ADAM12
Summary: This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602714 Ensembl IDEnsembl:ENSG00000148848 HGNC IDHGNC:HGNC:190 PHARMGKB IDPA24507 Map Location10q26.2 | |||||
GO terms in ADAM12
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008237 | metallopeptidase activity |
| MF | IPI | GO:0017124 | SH3 domain binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0006508 | proteolysis |
Gene expression in normal tissue: ADAM12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAM12
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | integrin_a9b1_pathway | Alpha9 beta1 integrin signaling events |
| pid | notch_pathway | Notch signaling pathway |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAM12
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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