ADAM12
Summary: This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ADAM metallopeptidase domain 12 | MIM:602714 | Ensembl:ENSG00000148848 | HGNC:HGNC:190 | PA24507 | 10q26.2 |
GO terms in ADAM12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004222 | metalloendopeptidase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008237 | metallopeptidase activity |
| MF | IPI | GO:0017124 | SH3 domain binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | TAS | GO:0007520 | myoblast fusion |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| CC | IEA | GO:0005576 | extracellular region |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
Gene expression in normal tissue: ADAM12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ADAM12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | integrin_a9b1_pathway | Alpha9 beta1 integrin signaling events |
| pid | notch_pathway | Notch signaling pathway |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| biocarta | cardiacegfpathway | role of egf receptor transactivation by gpcrs in cardiac hypertrophy |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-177929 | Signaling by EGFR |
| reactome | R-HSA-8941237 | Invadopodia formation |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 2 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD888 | Compound 44 | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD82 | Quiflapon | 1 |
| iGMDRD64 | Parbendazole | 4 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD248 | BRD4354 | 3 |
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD483 | SCH-529074 | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD499 | PDMP | 1 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD394 | BX-795 | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD901 | ELCPK | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ADAM12
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