RPN1

Summary: This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameribophorin I
OMIM IDMIM:180470
Ensembl IDEnsembl:ENSG00000163902
HGNC IDHGNC:HGNC:10381
PHARMGKB IDPA34777
Map Location3q21.3

Gene Categories:

DRUGGABLE GENOME

GO terms in RPN1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0006464 cellular protein modification process
BP IBA GO:0018279 protein N-linked glycosylation via asparagine
BP IMP GO:0018279 protein N-linked glycosylation via asparagine
BP TAS GO:0018279 protein N-linked glycosylation via asparagine
CC IDA GO:0005783 endoplasmic reticulum
CC TAS GO:0005789 endoplasmic reticulum membrane
Showing 1 to 6 of 17 rows rows per page

Gene expression in normal tissue: RPN1

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 31undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 3

Gene-drug pathway distribution

undefined10Protein stability and degradation1Ferroptosis1Longevity regulating pathway1Apoptosis regulation1Biosynthesis of secondary metabolites1PI3K/MTOR signaling1

Pathways in RPN1


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP183 Proteasome Degradation
kegg hsa00510 N-Glycan biosynthesis - Homo sapiens (human)
kegg hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
biocarta proteasomepathway proteasome complex
reactome R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
reactome R-HSA-392499 Metabolism of proteins
Showing 1 to 6 of 10 rows

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD138 PX 12 3
iGMDRD52 Rotenone 1
iGMDRD481 Dactolisib 3
iGMDRD398 Sepantronium 4
Showing 1 to 4 of 16 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPN1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.