RPN1
Summary: This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribophorin I | MIM:180470 | Ensembl:ENSG00000163902 | HGNC:HGNC:10381 | PA34777 | 3q21.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in RPN1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006464 | cellular protein modification process |
| BP | IBA | GO:0018279 | protein N-linked glycosylation via asparagine |
| BP | IMP | GO:0018279 | protein N-linked glycosylation via asparagine |
| BP | TAS | GO:0018279 | protein N-linked glycosylation via asparagine |
| CC | IDA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | ISS | GO:0005791 | rough endoplasmic reticulum |
| CC | IDA | GO:0005829 | cytosol |
| CC | IBA | GO:0008250 | oligosaccharyltransferase complex |
| CC | TAS | GO:0008250 | oligosaccharyltransferase complex |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0042470 | melanosome |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IBA | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| MF | TAS | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: RPN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPN1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP183 | Proteasome Degradation |
| kegg | hsa00510 | N-Glycan biosynthesis - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| biocarta | proteasomepathway | proteasome complex |
| reactome | R-HSA-1799339 | SRP-dependent cotranslational protein targeting to membrane |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-72766 | Translation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 3 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD398 | Sepantronium | 4 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD126 | Tipifarnib | 1 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD154 | NSC23766 | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPN1
CLASSFICATION
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