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PMS1

Summary: This gene encodes a protein belonging to the DNA mismatch repair mutL/hexB family. This protein is thought to be involved in the repair of DNA mismatches, and it can form heterodimers with MLH1, a known DNA mismatch repair protein. Mutations in this gene cause hereditary nonpolyposis colorectal cancer type 3 (HNPCC3) either alone or in combination with mutations in other genes involved in the HNPCC phenotype, which is also known as Lynch syndrome. [provided by RefSeq, Jul 2008].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
PMS1 homolog 1, mismatch repair system component	MIM:600258	Ensembl:ENSG00000064933	HGNC:HGNC:9121	PA33447	2q32.2

Gene Categories:

DRUG RESISTANCE DRUGGABLE GENOME CLINICALLY ACTIONABLE DNA REPAIR

GO terms in PMS1

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0006298	mismatch repair
BP	IEA	GO:0042493	response to drug
CC	TAS	GO:0005634	nucleus
CC	IBA	GO:0032300	mismatch repair complex
CC	IBA	GO:0032389	MutLalpha complex
MF	TAS	GO:0003677	DNA binding
MF	IBA	GO:0003697	single-stranded DNA binding
MF	IEA	GO:0005524	ATP binding
MF	IBA	GO:0016887	ATPase activity
MF	IEA	GO:0030983	mismatched DNA binding

Gene expression in normal tissue: PMS1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PMS1

Database	Pathway ID	Pathway Des.

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD193	Fqi1	2
iGMDRD398	Sepantronium	5
iGMDRD888	Compound 44	2
iGMDRD872	BRD7137	2
iGMDRD85	Ursolic acid	3
iGMDRD367	Ro 28-1675	3
iGMDRD394	BX-795	3
iGMDRD901	ELCPK	1
iGMDRD579	PF750	2
iGMDRD5	Tyrphostin AG 1478	2
iGMDRD77	Itraconazole	3
iGMDRD441	TW 37	1
iGMDRD226	ML006	2
iGMDRD427	ABT737	3
iGMDRD6	AM-580	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PMS1

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.