MACF1
Summary: This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microtubule-actin crosslinking factor 1 | MIM:608271 | Ensembl:ENSG00000127603 | HGNC:HGNC:13664 | PA30518 | 1p34.3 |
GO terms in MACF1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | HDA | GO:0003723 | RNA binding |
| MF | IDA | GO:0003779 | actin binding |
| MF | IBA | GO:0005198 | structural molecule activity |
| MF | IEA | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0016887 | ATPase activity |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IBA | GO:0045296 | cadherin binding |
| MF | IDA | GO:0051011 | microtubule minus-end binding |
| MF | IDA | GO:0051015 | actin filament binding |
| MF | NAS | GO:0051015 | actin filament binding |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | NAS | GO:0005856 | cytoskeleton |
| CC | IBA | GO:0005874 | microtubule |
| CC | IDA | GO:0005874 | microtubule |
| CC | IBA | GO:0005882 | intermediate filament |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0015629 | actin cytoskeleton |
| CC | IBA | GO:0016020 | membrane |
| CC | IDA | GO:0032587 | ruffle membrane |
| BP | ISS | GO:0010632 | regulation of epithelial cell migration |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | ISS | GO:0030177 | positive regulation of Wnt signaling pathway |
| BP | IDA | GO:0030334 | regulation of cell migration |
| BP | IBA | GO:0032886 | regulation of microtubule-based process |
| BP | IMP | GO:0032886 | regulation of microtubule-based process |
| BP | IBA | GO:0042060 | wound healing |
| BP | ISS | GO:0042060 | wound healing |
| BP | IDA | GO:0043001 | Golgi to plasma membrane protein transport |
| BP | IBA | GO:0045104 | intermediate filament cytoskeleton organization |
| BP | IDA | GO:0045773 | positive regulation of axon extension |
| BP | IBA | GO:0051893 | regulation of focal adhesion assembly |
| BP | IDA | GO:0051893 | regulation of focal adhesion assembly |
| BP | ISS | GO:0051893 | regulation of focal adhesion assembly |
Gene expression in normal tissue: MACF1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD453 | GW2580 | 1 |
| iGMDRD993 | QL-XII-61 | 1 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD585 | MPS1-IN-1 | 1 |
| iGMDRD571 | Cabozantinib | 1 |
| iGMDRD672 | Alectinib | 1 |
| iGMDRD1034 | WZ3105 | 1 |
| iGMDRD27 | WHI-P97 | 1 |
| iGMDRD125 | BIRB-796 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MACF1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.