S100A9


Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014].

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Gene Categories:

DRUGGABLE GENOMEPROTEASE

GO terms in S100A9


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0005509 calcium ion binding
MF IPI GO:0005515 protein binding
MF TAS GO:0008017 microtubule binding
MF TAS GO:0008270 zinc ion binding
MF IEA GO:0016209 antioxidant activity
MF TAS GO:0035662 Toll-like receptor 4 binding
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Gene expression in normal tissue: S100A9

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined25Leukocyte transendothelial migration1Other, kinases1Longevity regulating pathway1p53 pathway1Protein stability and degradation1

Pathways in S100A9


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Database
Pathway ID
Pathway Des.
wikipathways WP2865 IL1 and megakaryocytes in obesity
wikipathways WP2877 Vitamin D Receptor Pathway
pid toll_endogenous_pathway Endogenous TLR signaling
kegg hsa04657 IL-17 signaling pathway - Homo sapiens (human)
reactome R-HSA-168249 Innate Immune System
reactome R-HSA-168256 Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD316 N9-Isopropyl-olomoucine 3
iGMDRD61 Kinetin riboside 2
iGMDRD163 all trans Retinoic Acid 3
iGMDRD446 LY 2183240 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in S100A9

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Reference ID
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Cancer
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No matching records found

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