S100A9
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in the inhibition of casein kinase and altered expression of this protein is associated with the disease cystic fibrosis. This antimicrobial protein exhibits antifungal and antibacterial activity. [provided by RefSeq, Nov 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:123886 Ensembl IDEnsembl:ENSG00000163220 HGNC IDHGNC:HGNC:10499 PHARMGKB IDPA34911 Map Location1q21.3 | |||||
GO terms in S100A9
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0005509 | calcium ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008017 | microtubule binding |
| MF | TAS | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0016209 | antioxidant activity |
| MF | TAS | GO:0035662 | Toll-like receptor 4 binding |
Gene expression in normal tissue: S100A9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in S100A9
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2865 | IL1 and megakaryocytes in obesity |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| pid | toll_endogenous_pathway | Endogenous TLR signaling |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in S100A9
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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