RBBP8
Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:604124 Ensembl IDEnsembl:ENSG00000101773 HGNC IDHGNC:HGNC:9891 PHARMGKB IDPA34255 Map Location18q11.2 | |||||
GO terms in RBBP8
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity |
| MF | IMP | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity |
| MF | IBA | GO:0000403 | Y-form DNA binding |
| MF | IBA | GO:0000406 | double-strand/single-strand DNA junction binding |
| MF | IPI | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | IBA | GO:0003684 | damaged DNA binding |
Gene expression in normal tissue: RBBP8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBBP8
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atm_pathway | ATM pathway |
| pid | bard1pathway | BARD1 signaling events |
| pid | e2f_pathway | E2F transcription factor network |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | notch_pathway | Notch signaling pathway |
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBBP8
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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