RBBP8
Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| RB binding protein 8, endonuclease | MIM:604124 | Ensembl:ENSG00000101773 | HGNC:HGNC:9891 | PA34255 | 18q11.2 |
GO terms in RBBP8
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity |
| MF | IMP | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity |
| MF | IBA | GO:0000403 | Y-form DNA binding |
| MF | IBA | GO:0000406 | double-strand/single-strand DNA junction binding |
| MF | IPI | GO:0001103 | RNA polymerase II repressing transcription factor binding |
| MF | IBA | GO:0003684 | damaged DNA binding |
| MF | IDA | GO:0003684 | damaged DNA binding |
| MF | IBA | GO:0003690 | double-stranded DNA binding |
| MF | IBA | GO:0003697 | single-stranded DNA binding |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0070336 | flap-structured DNA binding |
| BP | IEA | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IBA | GO:0000724 | double-strand break repair via homologous recombination |
| BP | IDA | GO:0000724 | double-strand break repair via homologous recombination |
| BP | TAS | GO:0000724 | double-strand break repair via homologous recombination |
| BP | TAS | GO:0000729 | DNA double-strand break processing |
| BP | IEA | GO:0001835 | blastocyst hatching |
| BP | TAS | GO:0006260 | DNA replication |
| BP | TAS | GO:0006281 | DNA repair |
| BP | IBA | GO:0006289 | nucleotide-excision repair |
| BP | IMP | GO:0006289 | nucleotide-excision repair |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing |
| BP | IMP | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0051301 | cell division |
| BP | IEA | GO:0051321 | meiotic cell cycle |
| BP | TAS | GO:0070317 | negative regulation of G0 to G1 transition |
| BP | IEA | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
| BP | IEA | GO:1903507 | negative regulation of nucleic acid-templated transcription |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005694 | chromosome |
| CC | IDA | GO:0017053 | transcriptional repressor complex |
| CC | IBA | GO:0035861 | site of double-strand break |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: RBBP8
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RBBP8
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atm_pathway | ATM pathway |
| pid | bard1pathway | BARD1 signaling events |
| pid | e2f_pathway | E2F transcription factor network |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | notch_pathway | Notch signaling pathway |
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5685938 | HDR through Single Strand Annealing (SSA) |
| reactome | R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953750 | Transcriptional Regulation by E2F6 |
| reactome | R-HSA-912446 | Meiotic recombination |
| biocarta | atmpathway | atm signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD202 | Curcumin | 1 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD116 | CD437 | 5 |
| iGMDRD451 | Serdemetan | 4 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD399 | Selumetinib | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD802 | 4-methylfasudil | 6 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD152 | 179324-69-7 | 5 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD201 | SKI II | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD546 | BMS-754807 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RBBP8
CLASSFICATION
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