DOCK3


Summary: This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
dedicator of cytokinesis 3MIM:603123Ensembl:ENSG00000088538HGNC:HGNC:2989PA274553p21.2

GO terms in DOCK3


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0007264small GTPase mediated signal transduction
BPTASGO:1903997positive regulation of non-membrane spanning protein tyrosine kinase activity
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
MFIPIGO:0005515protein binding
MFIEAGO:0017124SH3 domain binding
MFTASGO:0030676Rac guanyl-nucleotide exchange factor activity

Gene expression in normal tissue: DOCK3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DOCK3


DatabasePathway IDPathway Des.
reactomeR-HSA-109582Hemostasis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006115Signaling by NTRK2 (TRKB)
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9032500Activated NTRK2 signals through FYN
reactomeR-HSA-9032500Activated NTRK2 signals through FYN
reactomeR-HSA-9032759NTRK2 activates RAC1
reactomeR-HSA-9032759NTRK2 activates RAC1
reactomeR-HSA-983231Factors involved in megakaryocyte development and platelet production
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD552AZD-17752
iGMDRD300Tozasertib2
iGMDRD42Vorinostat3
iGMDRD872BRD71373
iGMDRD871BRD63682
iGMDRD414MST-3123
iGMDRD366PI-1032
iGMDRD329Merck603
iGMDRD662JQ-11
iGMDRD434BMS-5369242
iGMDRD289Parthenolide3
iGMDRD705Nakiterpiosin3
iGMDRD77Itraconazole3
iGMDRD121GMX17783
iGMDRD158NSC1415404
iGMDRD137Indisulam2
iGMDRD271Brefeldin A4
iGMDRD103SN-385
iGMDRD5Tyrphostin AG 14781
iGMDRD177Teniposide3
iGMDRD901ELCPK3
iGMDRD341Triacsin c2
iGMDRD351GW843682X2
iGMDRD299ICL 6703
iGMDRD116CD4371
iGMDRD512nutlin 32
iGMDRD584VER 1550085
iGMDRD64Parbendazole1
iGMDRD369TGX-1153
iGMDRD451Serdemetan3
iGMDRD23Gossypol2
iGMDRD356PNU-746543
iGMDRD399Selumetinib5
iGMDRD506Fedratinib1
iGMDRD577BIX012942
iGMDRD782DC-45-A22
iGMDRD297Austocystin D1
iGMDRD446LY 21832401
iGMDRD193Fqi11
iGMDRD546BMS-7548073

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DOCK3

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