DOCK3
Summary: This gene is specifically expressed in the central nervous system (CNS). It encodes a member of the DOCK (dedicator of cytokinesis) family of guanine nucleotide exchange factors (GEFs). This protein, dedicator of cytokinesis 3 (DOCK3), is also known as modifier of cell adhesion (MOCA) and presenilin-binding protein (PBP). The DOCK3 and DOCK1, -2 and -4 share several conserved amino acids in their DHR-2 (DOCK homology region 2) domains that are required for GEF activity, and bind directly to WAVE proteins [Wiskott-Aldrich syndrome protein (WASP) family Verprolin-homologous proteins] via their DHR-1 domains. The DOCK3 induces axonal outgrowth in CNS by stimulating membrane recruitment of the WAVE complex and activating the small G protein Rac1. This gene is associated with an attention deficit hyperactivity disorder-like phenotype by a complex chromosomal rearrangement. [provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dedicator of cytokinesis 3 | MIM:603123 | Ensembl:ENSG00000088538 | HGNC:HGNC:2989 | PA27455 | 3p21.2 |
GO terms in DOCK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0007264 | small GTPase mediated signal transduction |
| BP | TAS | GO:1903997 | positive regulation of non-membrane spanning protein tyrosine kinase activity |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | TAS | GO:0030676 | Rac guanyl-nucleotide exchange factor activity |
Gene expression in normal tissue: DOCK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DOCK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-166520 | Signaling by NTRKs |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006115 | Signaling by NTRK2 (TRKB) |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-9032500 | Activated NTRK2 signals through FYN |
| reactome | R-HSA-9032500 | Activated NTRK2 signals through FYN |
| reactome | R-HSA-9032759 | NTRK2 activates RAC1 |
| reactome | R-HSA-9032759 | NTRK2 activates RAC1 |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD552 | AZD-1775 | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD662 | JQ-1 | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD158 | NSC141540 | 4 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD271 | Brefeldin A | 4 |
| iGMDRD103 | SN-38 | 5 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD299 | ICL 670 | 3 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD584 | VER 155008 | 5 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD399 | Selumetinib | 5 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD546 | BMS-754807 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DOCK3
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