DYRK1A
Summary: This gene encodes a member of the Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidine repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. This gene is a homolog of Drosophila mnb (minibrain) gene and rat Dyrk gene. It is localized in the Down syndrome critical region of chromosome 21, and is considered to be a strong candidate gene for learning defects associated with Down syndrome. Alternative splicing of this gene generates several transcript variants differing from each other either in the 5' UTR or in the 3' coding region. These variants encode at least five different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dual specificity tyrosine phosphorylation regulated kinase 1A | MIM:600855 | Ensembl:ENSG00000157540 | HGNC:HGNC:3091 | PA27545 | 21q22.13 |
GO terms in DYRK1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IGI | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | ISS | GO:0004713 | protein tyrosine kinase activity |
| MF | IDA | GO:0004715 | non-membrane spanning protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0042802 | identical protein binding |
| MF | ISS | GO:0043621 | protein self-association |
| MF | ISS | GO:0048156 | tau protein binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005856 | cytoskeleton |
| CC | ISS | GO:0016607 | nuclear speck |
| CC | TAS | GO:0016607 | nuclear speck |
| CC | ISS | GO:0030424 | axon |
| CC | ISS | GO:0030425 | dendrite |
| CC | IEA | GO:1990904 | ribonucleoprotein complex |
| BP | IEA | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007399 | nervous system development |
| BP | ISS | GO:0007623 | circadian rhythm |
| BP | IEA | GO:0016032 | viral process |
| BP | IGI | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0018105 | peptidyl-serine phosphorylation |
| BP | ISS | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IDA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | ISS | GO:0031115 | negative regulation of microtubule polymerization |
| BP | IDA | GO:0033120 | positive regulation of RNA splicing |
| BP | IMP | GO:0034205 | amyloid-beta formation |
| BP | TAS | GO:0036289 | peptidyl-serine autophosphorylation |
| BP | IDA | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | TAS | GO:0038083 | peptidyl-tyrosine autophosphorylation |
| BP | ISS | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| BP | ISS | GO:0046777 | protein autophosphorylation |
| BP | IEA | GO:0048025 | negative regulation of mRNA splicing, via spliceosome |
| BP | ISS | GO:0090312 | positive regulation of protein deacetylation |
Gene expression in normal tissue: DYRK1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DYRK1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Hedgehog | Hedgehog |
| netpath | Pathway_TCR | TCR |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD64 | Parbendazole | 1 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD433 | Lexibulin | 4 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD546 | BMS-754807 | 6 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD297 | Austocystin D | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DYRK1A
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