DCLK2


Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
doublecortin like kinase 2MIM:613166Ensembl:ENSG00000170390HGNC:HGNC:19002PA1623833664q31.23-q31.3

GO terms in DCLK2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0005524ATP binding
CCIEAGO:0005737cytoplasm
CCIEAGO:0005874microtubule
BPIBAGO:0000226microtubule cytoskeleton organization
BPIEAGO:0021766hippocampus development
BPIEAGO:0021860pyramidal neuron development
BPIEAGO:1900181negative regulation of protein localization to nucleus

Gene expression in normal tissue: DCLK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DCLK2


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD399Selumetinib2
iGMDRD100Zebularine1
iGMDRD286Nsc 6328392
iGMDRD871BRD63683
iGMDRD398Sepantronium2
iGMDRD64Parbendazole1
iGMDRD147Prima-11
iGMDRD60Quinoclamine6
iGMDRD353PD03259011
iGMDRD356PNU-746541
iGMDRD137Indisulam3
iGMDRD121GMX17782
iGMDRD77Itraconazole2
iGMDRD341Triacsin c3
iGMDRD61Kinetin riboside1
iGMDRD152179324-69-73
iGMDRD57Chloropentafluorobenzene2
iGMDRD123Isoevodiamine2
iGMDRD901ELCPK1
iGMDRD151CHM-12
iGMDRD772BRD47702
iGMDRD512nutlin 31
iGMDRD144NSC953972

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DCLK2

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