DCLK2


Summary: This gene encodes a member of the protein kinase superfamily and the doublecortin family. The protein encoded by this gene contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization, a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase, and a serine/proline-rich domain in between the doublecortin and the protein kinase domains, which mediates multiple protein-protein interactions. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Sep 2010].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in DCLK2


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0005524 ATP binding
CC IEA GO:0005737 cytoplasm
CC IEA GO:0005874 microtubule
BP IBA GO:0000226 microtubule cytoskeleton organization
BP IEA GO:0021766 hippocampus development
BP IEA GO:0021860 pyramidal neuron development
Showing 1 to 6 of 7 rows

Gene expression in normal tissue: DCLK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DCLK2


Loading, please wait...
Database
Pathway ID
Pathway Des.
No matching records found

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD399 Selumetinib 2
iGMDRD100 Zebularine 1
iGMDRD286 Nsc 632839 2
iGMDRD871 BRD6368 3
Showing 1 to 4 of 23 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DCLK2

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​