IL3


Summary: The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:147740
PHARMGKB IDPA29830
Map Location5q31.1

GO terms in IL3


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004713 protein tyrosine kinase activity
MF TAS GO:0005088 Ras guanyl-nucleotide exchange factor activity
MF TAS GO:0005135 interleukin-3 receptor binding
MF IEA GO:0008083 growth factor activity
BP TAS GO:0000165 MAPK cascade
BP TAS GO:0001959 regulation of cytokine-mediated signaling pathway
Showing 1 to 6 of 20 rows rows per page

Gene expression in normal tissue: IL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined17DNA replication1Chromatin histone acetylation1p53 pathway1Biosynthesis of secondary metabolites1

Pathways in IL3


Loading, please wait...
Database
Pathway ID
Pathway Des.
kegg hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
kegg hsa04210 Apoptosis - Homo sapiens (human)
kegg hsa04630 Jak-STAT signaling pathway - Homo sapiens (human)
kegg hsa04640 Hematopoietic cell lineage - Homo sapiens (human)
kegg hsa04664 Fc epsilon RI signaling pathway - Homo sapiens (human)
Showing 1 to 6 of 39 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD886 Compound 1541A 3
iGMDRD64 Parbendazole 2
iGMDRD246 NPC26 5
iGMDRD23 Gossypol 3
Showing 1 to 4 of 21 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in IL3

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​