IL3
Summary: The protein encoded by this gene is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| interleukin 3 | MIM:147740 | Ensembl:ENSG00000164399 | HGNC:HGNC:6011 | PA29830 | 5q31.1 |
GO terms in IL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005135 | interleukin-3 receptor binding |
| MF | IEA | GO:0008083 | growth factor activity |
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | TAS | GO:0001959 | regulation of cytokine-mediated signaling pathway |
| BP | IEA | GO:0006955 | immune response |
| BP | TAS | GO:0007267 | cell-cell signaling |
| BP | TAS | GO:0007399 | nervous system development |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IDA | GO:0035162 | embryonic hemopoiesis |
| BP | IDA | GO:0042531 | positive regulation of tyrosine phosphorylation of STAT protein |
| BP | ISS | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| CC | TAS | GO:0005576 | extracellular region |
| CC | ISS | GO:0005615 | extracellular space |
| CC | IEA | GO:0005622 | intracellular |
Gene expression in normal tissue: IL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in IL3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04630 | Jak-STAT signaling pathway - Homo sapiens (human) |
| kegg | hsa04640 | Hematopoietic cell lineage - Homo sapiens (human) |
| kegg | hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05221 | Acute myeloid leukemia - Homo sapiens (human) |
| kegg | hsa05310 | Asthma - Homo sapiens (human) |
| pid | il3_pathway | IL3-mediated signaling events |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | tcrcalciumpathway | Calcium signaling in the CD4+ TCR pathway |
| netpath | Pathway_IL3 | IL3 |
| smpdb | SMP00358 | Fc Epsilon Receptor I Signaling in Mast Cells |
| wikipathways | WP2848 | Differentiation Pathway |
| wikipathways | WP2849 | Hematopoietic Stem Cell Differentiation |
| wikipathways | WP286 | IL-3 Signaling Pathway |
| wikipathways | WP4105 | Transcriptional regulation by RUNX1 |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP530 | Cytokines and Inflammatory Response |
| wikipathways | WP615 | Senescence and Autophagy in Cancer |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-451927 | Interleukin-2 family signaling |
| reactome | R-HSA-512988 | Interleukin-3, Interleukin-5 and GM-CSF signaling |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939247 | RUNX1 regulates transcription of genes involved in interleukin signaling |
| reactome | R-HSA-912526 | Interleukin receptor SHC signaling |
| biocarta | badpathway | regulation of bad phosphorylation |
| biocarta | il3pathway | il 3 signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD577 | BIX01294 | 9 |
| iGMDRD780 | PP-30 | 4 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD210 | AC55649 | 5 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in IL3
CLASSFICATION
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