CLK4
Summary: The protein encoded by this gene belongs to the CDC2-like protein kinase (CLK) family. This protein kinase can interact with and phosphorylate the serine- and arginine-rich (SR) proteins, which are known to play an important role in the formation of spliceosomes, and thus may be involved in the regulation of alternative splicing. Studies in the Israeli sand rat Psammomys obesus suggested that the ubiquitin-like 5 (UBL5/BEACON), a highly conserved ubiquitin-like protein, may interact with and regulate the activity of this kinase. Multiple alternatively spliced transcript variants have been observed, but the full-length natures of which have not yet been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| CDC like kinase 4 | MIM:607969 | Ensembl:ENSG00000113240 | HGNC:HGNC:13659 | PA26598 | 5q35.3 |
GO terms in CLK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004712 | protein serine/threonine/tyrosine kinase activity |
| MF | IEA | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IMP | GO:0043484 | regulation of RNA splicing |
| BP | IEA | GO:0046777 | protein autophosphorylation |
| CC | IEA | GO:0005634 | nucleus |
Gene expression in normal tissue: CLK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD61 | Kinetin riboside | 4 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD356 | PNU-74654 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CLK4
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