SLC29A1
Summary: This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| solute carrier family 29 member 1 (Augustine blood group) | MIM:602193 | Ensembl:ENSG00000112759 | HGNC:HGNC:11003 | PA154 | 6p21.1 |
GO terms in SLC29A1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0006139 | nucleobase-containing compound metabolic process |
| BP | IEA | GO:0007595 | lactation |
| BP | IDA | GO:0015858 | nucleoside transport |
| BP | IBA | GO:0015862 | uridine transport |
| BP | IEA | GO:0015862 | uridine transport |
| BP | IEA | GO:0030431 | sleep |
| BP | IEA | GO:0060079 | excitatory postsynaptic potential |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0071456 | cellular response to hypoxia |
| BP | IEA | GO:1901642 | nucleoside transmembrane transport |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0016020 | membrane |
| CC | IBA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | IEA | GO:0098794 | postsynapse |
| MF | IBA | GO:0005337 | nucleoside transmembrane transporter activity |
| MF | TAS | GO:0005337 | nucleoside transmembrane transporter activity |
Gene expression in normal tissue: SLC29A1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SLC29A1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-425397 | Transport of vitamins, nucleosides, and related molecules |
| reactome | R-HSA-425407 | SLC-mediated transmembrane transport |
| reactome | R-HSA-83936 | Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane |
| smpdb | SMP00427 | Azathioprine Action Pathway |
| smpdb | SMP00428 | Mercaptopurine Action Pathway |
| smpdb | SMP00430 | Thioguanine Action Pathway |
| smpdb | SMP00446 | Gemcitabine Action Pathway |
| smpdb | SMP00603 | Gemcitabine Metabolism Pathway |
| smpdb | SMP00609 | Mercaptopurine Metabolism Pathway |
| wikipathways | WP1601 | Fluoropyrimidine Activity |
| kegg | hsa05034 | Alcoholism - Homo sapiens (human) |
| pharmgkb | PA150653776 | Fluoropyrimidine Pathway, Pharmacokinetics |
| pharmgkb | PA2036 | Gemcitabine Pathway, Pharmacodynamics |
| pharmgkb | PA2040 | Thiopurine Pathway, Pharmacokinetics/Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD945 | ML214 | 5 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD270 | Ciclosporin | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SLC29A1
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