PKN3
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase N3 | MIM:610714 | Ensembl:ENSG00000160447 | HGNC:HGNC:17999 | PA134919098 | 9q34.11 |
GO terms in PKN3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004697 | protein kinase C activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0017049 | GTP-Rho binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | TAS | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0048471 | perinuclear region of cytoplasm |
| BP | TAS | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IDA | GO:0010631 | epithelial cell migration |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
Gene expression in normal tissue: PKN3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PKN3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-5625740 | RHO GTPases activate PKNs |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 3 |
| iGMDRD219 | Bax channel blocker | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD885 | Compound 110 | 6 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD886 | Compound 1541A | 6 |
| iGMDRD300 | Tozasertib | 9 |
| iGMDRD577 | BIX01294 | 6 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD887 | Compound 23 citrate | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PKN3
CLASSFICATION
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