FBXO43

Summary: Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameF-box protein 43
OMIM IDMIM:609110
Ensembl IDEnsembl:ENSG00000156509
HGNC IDHGNC:HGNC:28521
PHARMGKB IDPA134913061
Map Location8q22.2

Gene Categories:

TUMOR SUPPRESSOR

GO terms in FBXO43


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0046872 metal ion binding
CC IBA GO:0005634 nucleus
BP IBA GO:0007088 regulation of mitotic nuclear division
BP IEA GO:0016567 protein ubiquitination
BP IBA GO:0045835 negative regulation of meiotic nuclear division
BP IEA GO:0051321 meiotic cell cycle
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Gene expression in normal tissue: FBXO43

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 23undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 73

Gene-drug pathway distribution

undefined28Ferroptosis1Stilbenoid, diarylheptanoid and gingerol biosynthesis1p53 pathway1ERK MAPK signaling1One carbon pool by folate1Apoptosis regulation1

Pathways in FBXO43


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Database
Pathway ID
Pathway Des.
kegg hsa04114 Oocyte meiosis - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD433 Lexibulin 3
iGMDRD144 NSC95397 3
iGMDRD779 PRL-3 Inhibitor I 2
iGMDRD670 ML 210 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FBXO43

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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