FBXO43
Summary: Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
NameF-box protein 43 OMIM IDMIM:609110 Ensembl IDEnsembl:ENSG00000156509 HGNC IDHGNC:HGNC:28521 PHARMGKB IDPA134913061 Map Location8q22.2 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in FBXO43
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0005634 | nucleus |
| BP | IBA | GO:0007088 | regulation of mitotic nuclear division |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IBA | GO:0045835 | negative regulation of meiotic nuclear division |
| BP | IEA | GO:0051321 | meiotic cell cycle |
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Gene expression in normal tissue: FBXO43
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FBXO43
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
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Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FBXO43
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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