LRP6

Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NameLDL receptor related protein 6
OMIM IDMIM:603507
Ensembl IDEnsembl:ENSG00000070018
HGNC IDHGNC:HGNC:6698
PHARMGKB IDPA30456
Map Location12p13.2

GO terms in LRP6


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0005041 low-density lipoprotein particle receptor activity
MF IDA GO:0005041 low-density lipoprotein particle receptor activity
MF IPI GO:0005102 signaling receptor binding
MF IPI GO:0005109 frizzled binding
MF IPI GO:0005515 protein binding
MF IBA GO:0015026 coreceptor activity
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Gene expression in normal tissue: LRP6

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 64undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 6LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 23UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 3

Gene-drug pathway distribution

undefined29Apoptosis regulation2IGFR signaling1Longevity regulating pathway1Leukocyte transendothelial migration1Biosynthesis of secondary metabolites1Metabolic pathways1PI3K/MTOR signaling1Purine metabolism1

Pathways in LRP6


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Database
Pathway ID
Pathway Des.
wikipathways WP1544 MicroRNAs in cardiomyocyte hypertrophy
wikipathways WP2572 Primary Focal Segmental Glomerulosclerosis FSGS
wikipathways WP2804 Hair Follicle Development- Induction (Part 1 of 3)
wikipathways WP363 Wnt Signaling Pathway
wikipathways WP3658 Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathways WP3931 ESC Pluripotency Pathways
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD192 CIL56 4
iGMDRD267 Oligomycin A 3
iGMDRD77 Itraconazole 1
iGMDRD414 MST-312 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LRP6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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