LRP6


Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
LDL receptor related protein 6MIM:603507Ensembl:ENSG00000070018HGNC:HGNC:6698PA3045612p13.2

GO terms in LRP6


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0005041low-density lipoprotein particle receptor activity
MFIDAGO:0005041low-density lipoprotein particle receptor activity
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005109frizzled binding
MFIPIGO:0005515protein binding
MFIBAGO:0015026coreceptor activity
MFIPIGO:0017147Wnt-protein binding
MFTASGO:0017147Wnt-protein binding
MFIMPGO:0019210kinase inhibitor activity
MFIMPGO:0019534toxin transmembrane transporter activity
MFIMPGO:0019534toxin transmembrane transporter activity
MFIBAGO:0034185apolipoprotein binding
MFIPIGO:0042802identical protein binding
MFIPIGO:0042803protein homodimerization activity
MFIDAGO:0071936coreceptor activity involved in Wnt signaling pathway
MFNASGO:1904928coreceptor activity involved in canonical Wnt signaling pathway
BPIBAGO:0001702gastrulation with mouth forming second
BPIBAGO:0001843neural tube closure
BPIMPGO:0001933negative regulation of protein phosphorylation
BPIBAGO:0003344pericardium morphogenesis
BPIMPGO:0006469negative regulation of protein kinase activity
BPIEAGO:0007204positive regulation of cytosolic calcium ion concentration
BPIBAGO:0007268chemical synaptic transmission
BPIBAGO:0009880embryonic pattern specification
BPIBAGO:0009952anterior/posterior pattern specification
BPIBAGO:0014029neural crest formation
BPIDAGO:0014029neural crest formation
BPIBAGO:0014033neural crest cell differentiation
BPIDAGO:0014033neural crest cell differentiation
BPIDAGO:0016055Wnt signaling pathway
BPIMPGO:0016055Wnt signaling pathway
BPIBAGO:0021587cerebellum morphogenesis
BPIBAGO:0021794thalamus development
BPIBAGO:0021987cerebral cortex development
BPIBAGO:0030278regulation of ossification
BPIBAGO:0030326embryonic limb morphogenesis
BPIBAGO:0030901midbrain development
BPIBAGO:0030917midbrain-hindbrain boundary development
BPIMPGO:0034392negative regulation of smooth muscle cell apoptotic process
BPIBAGO:0035261external genitalia morphogenesis
BPIBAGO:0042475odontogenesis of dentin-containing tooth
BPIEAGO:0043434response to peptide hormone
BPIDAGO:0044332Wnt signaling pathway involved in dorsal/ventral axis specification
BPICGO:0044335canonical Wnt signaling pathway involved in neural crest cell differentiation
BPICGO:0044340canonical Wnt signaling pathway involved in regulation of cell proliferation
BPIMPGO:0045787positive regulation of cell cycle
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIBAGO:0046849bone remodeling
BPIBAGO:0048596embryonic camera-type eye morphogenesis
BPIBAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPIBAGO:0060021roof of mouth development
BPIBAGO:0060026convergent extension
BPIBAGO:0060059embryonic retina morphogenesis in camera-type eye
BPIDAGO:0060070canonical Wnt signaling pathway
BPIMPGO:0060070canonical Wnt signaling pathway
BPTASGO:0060070canonical Wnt signaling pathway
BPIBAGO:0060325face morphogenesis
BPIBAGO:0060349bone morphogenesis
BPIBAGO:0060444branching involved in mammary gland duct morphogenesis
BPIBAGO:0060535trachea cartilage morphogenesis
BPIGIGO:0060828regulation of canonical Wnt signaling pathway
BPIMPGO:0071397cellular response to cholesterol
BPISSGO:0071542dopaminergic neuron differentiation
BPIDAGO:0071901negative regulation of protein serine/threonine kinase activity
BPIPIGO:0072659protein localization to plasma membrane
BPIBAGO:0090009primitive streak formation
BPTASGO:0090090negative regulation of canonical Wnt signaling pathway
BPIBAGO:0090118receptor-mediated endocytosis involved in cholesterol transport
BPIBAGO:0090244Wnt signaling pathway involved in somitogenesis
BPIBAGO:0090245axis elongation involved in somitogenesis
BPIDAGO:0090263positive regulation of canonical Wnt signaling pathway
BPIEAGO:0098609cell-cell adhesion
BPIEAGO:1901998toxin transport
BPTASGO:1904886beta-catenin destruction complex disassembly
BPTASGO:1904948midbrain dopaminergic neuron differentiation
BPTASGO:1904953Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
BPIDAGO:2000055positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
CCTASGO:0005576extracellular region
CCIDAGO:0005769early endosome
CCIEAGO:0005783endoplasmic reticulum
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005901caveola
CCIDAGO:0005901caveola
CCIBAGO:0009986cell surface
CCIDAGO:0009986cell surface
CCIEAGO:0016021integral component of membrane
CCIDAGO:0031410cytoplasmic vesicle
CCTASGO:0031901early endosome membrane
CCIBAGO:0043025neuronal cell body
CCIBAGO:0045202synapse
CCIDAGO:1990851Wnt-Frizzled-LRP5/6 complex
CCIPIGO:1990851Wnt-Frizzled-LRP5/6 complex
CCTASGO:1990851Wnt-Frizzled-LRP5/6 complex
CCIDAGO:1990909Wnt signalosome
CCNASGO:1990909Wnt signalosome

Gene expression in normal tissue: LRP6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LRP6


DatabasePathway IDPathway Des.
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP2572Primary Focal Segmental Glomerulosclerosis FSGS
wikipathwaysWP2804Hair Follicle Development- Induction (Part 1 of 3)
wikipathwaysWP363Wnt Signaling Pathway
wikipathwaysWP3658Wnt-beta-catenin Signaling Pathway in Leukemia
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP399Wnt Signaling Pathway and Pluripotency
wikipathwaysWP4150Wnt Signaling in Kidney Disease
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP428Wnt Signaling Pathway
pidbetacatenin_deg_pathwayDegradation of beta catenin
pidps1pathwayPresenilin action in Notch and Wnt signaling
pidwnt_canonical_pathwayCanonical Wnt signaling pathway
pidwnt_signaling_pathwayWnt signaling network
kegghsa04150mTOR signaling pathway - Homo sapiens (human)
kegghsa04310Wnt signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05225Hepatocellular carcinoma - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
netpathPathway_WntWnt
biocartagsk3pathwayinactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages
biocartahespathwaysegmentation clock
biocartapitx2pathwaymulti-step regulation of transcription by pitx2
biocartawntlrp6pathwaywnt lrp6 signalling
biocartawntpathwaywnt signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-3772470Negative regulation of TCF-dependent signaling by WNT ligand antagonists
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membrane
reactomeR-HSA-4641263Regulation of FZD by ubiquitination
reactomeR-HSA-4791275Signaling by WNT in cancer
reactomeR-HSA-5340588RNF mutants show enhanced WNT signaling and proliferation
reactomeR-HSA-5663202Diseases of signal transduction

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD192CIL564
iGMDRD267Oligomycin A3
iGMDRD77Itraconazole1
iGMDRD414MST-3124
iGMDRD871BRD63683
iGMDRD882CIL413
iGMDRD872BRD71373
iGMDRD307Manumycin A3
iGMDRD512nutlin 31
iGMDRD560MK-22062
iGMDRD79Gemcitabine2
iGMDRD85Ursolic acid6
iGMDRD499PDMP3
iGMDRD511CHEMBL3993793
iGMDRD255SB2250022
iGMDRD207Capsaicin3
iGMDRD782DC-45-A23
iGMDRD226ML0063
iGMDRD318PAC-14
iGMDRD52Rotenone3
iGMDRD187BRD98763
iGMDRD294Batimastat1
iGMDRD188Piperlongumine3
iGMDRD562Navitoclax4
iGMDRD64Parbendazole3
iGMDRD60Quinoclamine4
iGMDRD356PNU-746543
iGMDRD874BRD89583
iGMDRD524ISX-91
iGMDRD126Tipifarnib2
iGMDRD889Compound 7d-cis1
iGMDRD772BRD47702
iGMDRD579PF7502
iGMDRD546BMS-7548073
iGMDRD781Sirolimus2
iGMDRD201SKI II3
iGMDRD61Kinetin riboside5
iGMDRD394BX-7951

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LRP6

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