LRP6
Summary: This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LDL receptor related protein 6 | MIM:603507 | Ensembl:ENSG00000070018 | HGNC:HGNC:6698 | PA30456 | 12p13.2 |
GO terms in LRP6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005041 | low-density lipoprotein particle receptor activity |
| MF | IDA | GO:0005041 | low-density lipoprotein particle receptor activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005109 | frizzled binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0015026 | coreceptor activity |
| MF | IPI | GO:0017147 | Wnt-protein binding |
| MF | TAS | GO:0017147 | Wnt-protein binding |
| MF | IMP | GO:0019210 | kinase inhibitor activity |
| MF | IMP | GO:0019534 | toxin transmembrane transporter activity |
| MF | IMP | GO:0019534 | toxin transmembrane transporter activity |
| MF | IBA | GO:0034185 | apolipoprotein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IDA | GO:0071936 | coreceptor activity involved in Wnt signaling pathway |
| MF | NAS | GO:1904928 | coreceptor activity involved in canonical Wnt signaling pathway |
| BP | IBA | GO:0001702 | gastrulation with mouth forming second |
| BP | IBA | GO:0001843 | neural tube closure |
| BP | IMP | GO:0001933 | negative regulation of protein phosphorylation |
| BP | IBA | GO:0003344 | pericardium morphogenesis |
| BP | IMP | GO:0006469 | negative regulation of protein kinase activity |
| BP | IEA | GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| BP | IBA | GO:0007268 | chemical synaptic transmission |
| BP | IBA | GO:0009880 | embryonic pattern specification |
| BP | IBA | GO:0009952 | anterior/posterior pattern specification |
| BP | IBA | GO:0014029 | neural crest formation |
| BP | IDA | GO:0014029 | neural crest formation |
| BP | IBA | GO:0014033 | neural crest cell differentiation |
| BP | IDA | GO:0014033 | neural crest cell differentiation |
| BP | IDA | GO:0016055 | Wnt signaling pathway |
| BP | IMP | GO:0016055 | Wnt signaling pathway |
| BP | IBA | GO:0021587 | cerebellum morphogenesis |
| BP | IBA | GO:0021794 | thalamus development |
| BP | IBA | GO:0021987 | cerebral cortex development |
| BP | IBA | GO:0030278 | regulation of ossification |
| BP | IBA | GO:0030326 | embryonic limb morphogenesis |
| BP | IBA | GO:0030901 | midbrain development |
| BP | IBA | GO:0030917 | midbrain-hindbrain boundary development |
| BP | IMP | GO:0034392 | negative regulation of smooth muscle cell apoptotic process |
| BP | IBA | GO:0035261 | external genitalia morphogenesis |
| BP | IBA | GO:0042475 | odontogenesis of dentin-containing tooth |
| BP | IEA | GO:0043434 | response to peptide hormone |
| BP | IDA | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification |
| BP | IC | GO:0044335 | canonical Wnt signaling pathway involved in neural crest cell differentiation |
| BP | IC | GO:0044340 | canonical Wnt signaling pathway involved in regulation of cell proliferation |
| BP | IMP | GO:0045787 | positive regulation of cell cycle |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0046849 | bone remodeling |
| BP | IBA | GO:0048596 | embryonic camera-type eye morphogenesis |
| BP | IBA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IBA | GO:0060021 | roof of mouth development |
| BP | IBA | GO:0060026 | convergent extension |
| BP | IBA | GO:0060059 | embryonic retina morphogenesis in camera-type eye |
| BP | IDA | GO:0060070 | canonical Wnt signaling pathway |
| BP | IMP | GO:0060070 | canonical Wnt signaling pathway |
| BP | TAS | GO:0060070 | canonical Wnt signaling pathway |
| BP | IBA | GO:0060325 | face morphogenesis |
| BP | IBA | GO:0060349 | bone morphogenesis |
| BP | IBA | GO:0060444 | branching involved in mammary gland duct morphogenesis |
| BP | IBA | GO:0060535 | trachea cartilage morphogenesis |
| BP | IGI | GO:0060828 | regulation of canonical Wnt signaling pathway |
| BP | IMP | GO:0071397 | cellular response to cholesterol |
| BP | ISS | GO:0071542 | dopaminergic neuron differentiation |
| BP | IDA | GO:0071901 | negative regulation of protein serine/threonine kinase activity |
| BP | IPI | GO:0072659 | protein localization to plasma membrane |
| BP | IBA | GO:0090009 | primitive streak formation |
| BP | TAS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IBA | GO:0090118 | receptor-mediated endocytosis involved in cholesterol transport |
| BP | IBA | GO:0090244 | Wnt signaling pathway involved in somitogenesis |
| BP | IBA | GO:0090245 | axis elongation involved in somitogenesis |
| BP | IDA | GO:0090263 | positive regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:0098609 | cell-cell adhesion |
| BP | IEA | GO:1901998 | toxin transport |
| BP | TAS | GO:1904886 | beta-catenin destruction complex disassembly |
| BP | TAS | GO:1904948 | midbrain dopaminergic neuron differentiation |
| BP | TAS | GO:1904953 | Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation |
| BP | IDA | GO:2000055 | positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005769 | early endosome |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005901 | caveola |
| CC | IDA | GO:0005901 | caveola |
| CC | IBA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | TAS | GO:0031901 | early endosome membrane |
| CC | IBA | GO:0043025 | neuronal cell body |
| CC | IBA | GO:0045202 | synapse |
| CC | IDA | GO:1990851 | Wnt-Frizzled-LRP5/6 complex |
| CC | IPI | GO:1990851 | Wnt-Frizzled-LRP5/6 complex |
| CC | TAS | GO:1990851 | Wnt-Frizzled-LRP5/6 complex |
| CC | IDA | GO:1990909 | Wnt signalosome |
| CC | NAS | GO:1990909 | Wnt signalosome |
Gene expression in normal tissue: LRP6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LRP6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP2804 | Hair Follicle Development- Induction (Part 1 of 3) |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3658 | Wnt-beta-catenin Signaling Pathway in Leukemia |
| wikipathways | WP3931 | ESC Pluripotency Pathways |
| wikipathways | WP399 | Wnt Signaling Pathway and Pluripotency |
| wikipathways | WP4150 | Wnt Signaling in Kidney Disease |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
| wikipathways | WP428 | Wnt Signaling Pathway |
| pid | betacatenin_deg_pathway | Degradation of beta catenin |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| pid | wnt_canonical_pathway | Canonical Wnt signaling pathway |
| pid | wnt_signaling_pathway | Wnt signaling network |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05224 | Breast cancer - Homo sapiens (human) |
| kegg | hsa05225 | Hepatocellular carcinoma - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| netpath | Pathway_Wnt | Wnt |
| biocarta | gsk3pathway | inactivation of gsk3 by akt causes accumulation of b-catenin in alveolar macrophages |
| biocarta | hespathway | segmentation clock |
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| biocarta | wntlrp6pathway | wnt lrp6 signalling |
| biocarta | wntpathway | wnt signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-3772470 | Negative regulation of TCF-dependent signaling by WNT ligand antagonists |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4641262 | Disassembly of the destruction complex and recruitment of AXIN to the membrane |
| reactome | R-HSA-4641263 | Regulation of FZD by ubiquitination |
| reactome | R-HSA-4791275 | Signaling by WNT in cancer |
| reactome | R-HSA-5340588 | RNF mutants show enhanced WNT signaling and proliferation |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD192 | CIL56 | 4 |
| iGMDRD267 | Oligomycin A | 3 |
| iGMDRD77 | Itraconazole | 1 |
| iGMDRD414 | MST-312 | 4 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD560 | MK-2206 | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD85 | Ursolic acid | 6 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD207 | Capsaicin | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD318 | PAC-1 | 4 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD874 | BRD8958 | 3 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD546 | BMS-754807 | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD61 | Kinetin riboside | 5 |
| iGMDRD394 | BX-795 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LRP6
CLASSFICATION
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