HOXD10
Summary: This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox D genes located on chromosome 2. The encoded nuclear protein functions as a sequence-specific transcription factor that is expressed in the developing limb buds and is involved in differentiation and limb development. Mutations in this gene have been associated with Wilm's tumor and congenital vertical talus (also known as 'rocker-bottom foot' deformity or congenital convex pes valgus) and/or a foot deformity resembling that seen in Charcot-Marie-Tooth disease. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeobox D10 | MIM:142984 | Ensembl:ENSG00000128710 | HGNC:HGNC:5133 | PA29407 | 2q31.1 |
GO terms in HOXD10
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | IDA | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007338 | single fertilization |
| BP | IEA | GO:0007519 | skeletal muscle tissue development |
| BP | IEA | GO:0008344 | adult locomotory behavior |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0009954 | proximal/distal pattern formation |
| BP | IEA | GO:0021520 | spinal cord motor neuron cell fate specification |
| BP | IEA | GO:0030326 | embryonic limb morphogenesis |
| BP | IEA | GO:0035136 | forelimb morphogenesis |
| BP | IEA | GO:0035137 | hindlimb morphogenesis |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0048704 | embryonic skeletal system morphogenesis |
| BP | IEA | GO:0048935 | peripheral nervous system neuron development |
| BP | IEA | GO:0050905 | neuromuscular process |
| MF | IEA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0003682 | chromatin binding |
Gene expression in normal tissue: HOXD10
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HOXD10
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD486 | Tosedostat | 1 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD640 | CAY10618 | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD366 | PI-103 | 1 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD329 | Merck60 | 9 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD202 | Curcumin | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HOXD10
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