FGFR1OP
Summary: This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| FGFR1 oncogene partner | MIM:605392 | Ensembl:ENSG00000213066 | HGNC:HGNC:17012 | PA134941638 | 6q27 |
GO terms in FGFR1OP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004713 | protein tyrosine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IDA | GO:0030292 | protein tyrosine kinase inhibitor activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0018108 | peptidyl-tyrosine phosphorylation |
| BP | IDA | GO:0030307 | positive regulation of cell growth |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0034453 | microtubule anchoring |
| BP | IEA | GO:0061099 | negative regulation of protein tyrosine kinase activity |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005813 | centrosome |
| CC | IEA | GO:0005814 | centriole |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0042995 | cell projection |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: FGFR1OP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGFR1OP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pharmgkb | PA2032 | VEGF Signaling Pathway |
| reactome | R-HSA-1226099 | Signaling by FGFR in disease |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
| reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-5655302 | Signaling by FGFR1 in disease |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD159 | 3-Chloro-L-alanine | 1 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD433 | Lexibulin | 1 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD144 | NSC95397 | 8 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD577 | BIX01294 | 8 |
| iGMDRD188 | Piperlongumine | 8 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD260 | FQI-2 | 3 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD52 | Rotenone | 1 |
| iGMDRD698 | Neratinib | 2 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD883 | CIL55A | 5 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD251 | ML162 | 5 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD705 | Nakiterpiosin | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGFR1OP
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