FGFR1OP
Summary: This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:605392 Ensembl IDEnsembl:ENSG00000213066 HGNC IDHGNC:HGNC:17012 PHARMGKB IDPA134941638 Map Location6q27 |
GO terms in FGFR1OP
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | TAS | GO:0004713 | protein tyrosine kinase activity |
MF | IPI | GO:0005515 | protein binding |
MF | IPI | GO:0019901 | protein kinase binding |
MF | IDA | GO:0030292 | protein tyrosine kinase inhibitor activity |
MF | IDA | GO:0042803 | protein homodimerization activity |
BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
Gene expression in normal tissue: FGFR1OP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGFR1OP
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Database | Pathway ID | Pathway Des. |
---|---|---|
pharmgkb | PA2032 | VEGF Signaling Pathway |
reactome | R-HSA-1226099 | Signaling by FGFR in disease |
reactome | R-HSA-1640170 | Cell Cycle |
reactome | R-HSA-1643685 | Disease |
reactome | R-HSA-1839117 | Signaling by cytosolic FGFR1 fusion mutants |
reactome | R-HSA-1839124 | FGFR1 mutant receptor activation |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in FGFR1OP
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |