FGFR1OP


Summary: This gene encodes a largely hydrophilic centrosomal protein that is required for anchoring microtubules to subcellular structures. A t(6;8)(q27;p11) chromosomal translocation, fusing this gene and the fibroblast growth factor receptor 1 (FGFR1) gene, has been found in cases of myeloproliferative disorder. The resulting chimeric protein contains the N-terminal leucine-rich region of this encoded protein fused to the catalytic domain of FGFR1. Alterations in this gene may also be associated with Crohn's disease, Graves' disease, and vitiligo. Alternatively spliced transcript variants that encode different proteins have been identified. [provided by RefSeq, Jul 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:605392
PHARMGKB IDPA134941638
Map Location6q27

GO terms in FGFR1OP


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Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0004713 protein tyrosine kinase activity
MF IPI GO:0005515 protein binding
MF IPI GO:0019901 protein kinase binding
MF IDA GO:0030292 protein tyrosine kinase inhibitor activity
MF IDA GO:0042803 protein homodimerization activity
BP TAS GO:0000086 G2/M transition of mitotic cell cycle
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Gene expression in normal tissue: FGFR1OP

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 67undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 9LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 37UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 2

Gene-drug pathway distribution

undefined30Chromatin histone acetylation1DNA replication1Biosynthesis of secondary metabolites1Other, kinases1

Pathways in FGFR1OP


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Database
Pathway ID
Pathway Des.
pharmgkb PA2032 VEGF Signaling Pathway
reactome R-HSA-1226099 Signaling by FGFR in disease
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-1643685 Disease
reactome R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
reactome R-HSA-1839124 FGFR1 mutant receptor activation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD193 Fqi1 4
iGMDRD446 LY 2183240 5
iGMDRD159 3-Chloro-L-alanine 1
iGMDRD280 CYTOCHALASIN B 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGFR1OP

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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