XRN1
Summary: This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:607994 Ensembl IDEnsembl:ENSG00000114127 HGNC IDHGNC:HGNC:30654 PHARMGKB IDPA134878471 Map Location3q23 | |||||
GO terms in XRN1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | ISS | GO:0002151 | G-quadruplex RNA binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IMP | GO:0004534 | 5'-3' exoribonuclease activity |
| MF | ISS | GO:0004534 | 5'-3' exoribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0051880 | G-quadruplex DNA binding |
Gene expression in normal tissue: XRN1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in XRN1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa03008 | Ribosome biogenesis in eukaryotes - Homo sapiens (human) |
| kegg | hsa03018 | RNA degradation - Homo sapiens (human) |
| reactome | R-HSA-429914 | Deadenylation-dependent mRNA decay |
| reactome | R-HSA-430039 | mRNA decay by 5' to 3' exoribonuclease |
| reactome | R-HSA-450385 | Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA |
| reactome | R-HSA-450513 | Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in XRN1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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