iGMDRD461

Canonical SMILES: CC1=CN=C(N=C1C2=CNC(=C2)C(=O)NC(CO)C3=CC(=CC=C3)Cl)NC4=C(C=C(C=C4)F)Cl

InChI: InChI=1S/C24H20Cl2FN5O2/c1-13-10-29-24(31-19-6-5-17(27)9-18(19)26)32-22(13)15-8-20(28-11-15)23(34)30-21(12-33)14-3-2-4-16(25)7-14/h2-11,21,28,33H,12H2,1H3,(H,30,34)(H,29,31,32)/t21-/m1/s1

InChI Key: WUTVMXLIGHTZJC-OAQYLSRUSA-N

Standard NamePubchem CIDDrug StatusDrug Type
VX-11e11634700AloneSmall Molecule

Drug Targets:

ERK

Drug Pathways:

ERK MAPK signaling

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot


Gene IDGene NameModel Num.
3845KRAS1
8289ARID1A2
55252ASXL21
2033EP3002
10664CTCF1
1029CDKN2A2
7422VEGFA1
4089SMAD41
54894RNF431
673BRAF2
171023ASXL11
4261CIITA1
4893NRAS1
2146EZH21

Gene in drug-gene network: Network Plot

Models in VX-11e

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