CTCF


Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:604167
PHARMGKB IDPA26998
Map Location16q22.1

GO terms in CTCF


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0007059 chromosome segregation
BP IMP GO:0008285 negative regulation of cell proliferation
BP IMP GO:0010628 positive regulation of gene expression
BP IDA GO:0016584 nucleosome positioning
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Gene expression in normal tissue: CTCF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

ERK MAPK signaling1Chromatin histone acetylation1

Pathways in CTCF


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Database
Pathway ID
Pathway Des.
wikipathways WP3584 MECP2 and Associated Rett Syndrome
wikipathways WP3995 Prion disease pathway
wikipathways WP706 Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
netpath Pathway_TGF_beta_Receptor TGF_beta_Receptor
biocarta ctcfpathway ctcf: first multivalent nuclear factor
reactome R-HSA-1266738 Developmental Biology
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD678 Tubastatin A 1
iGMDRD461 VX-11e 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTCF

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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