Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].

CCCTC-binding factorMIM:604167Ensembl:ENSG00000102974HGNC:HGNC:13723PA2699816q22.1

GO terms in CTCF

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0007059chromosome segregation
BPIMPGO:0008285negative regulation of cell proliferation
BPIMPGO:0010628positive regulation of gene expression
BPIDAGO:0016584nucleosome positioning
BPIMPGO:0040029regulation of gene expression, epigenetic
BPIMPGO:0040030regulation of molecular function, epigenetic
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:0045893positive regulation of transcription, DNA-templated
BPIMPGO:0045893positive regulation of transcription, DNA-templated
BPIBAGO:0045944positive regulation of transcription by RNA polymerase II
BPNASGO:0070602regulation of centromeric sister chromatid cohesion
BPIMPGO:0071459protein localization to chromosome, centromeric region
CCIDAGO:0000775chromosome, centromeric region
CCIDAGO:0000793condensed chromosome
MFIDAGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0001078transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIBAGO:0003700DNA-binding transcription factor activity
MFIDAGO:0003700DNA-binding transcription factor activity
MFTASGO:0003714transcription corepressor activity
MFIPIGO:0005515protein binding
MFTASGO:0008270zinc ion binding
MFIDAGO:0043035chromatin insulator sequence binding
MFIDAGO:0043565sequence-specific DNA binding
MFIBAGO:0044212transcription regulatory region DNA binding
MFIDAGO:0044212transcription regulatory region DNA binding

Gene expression in normal tissue: CTCF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CTCF

DatabasePathway IDPathway Des.
wikipathwaysWP3584MECP2 and Associated Rett Syndrome
wikipathwaysWP3995Prion disease pathway
wikipathwaysWP706Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways
biocartactcfpathwayctcf: first multivalent nuclear factor
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-5617472Activation of anterior HOX genes in hindbrain development during early embryogenesis
reactomeR-HSA-5619507Activation of HOX genes during differentiation

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.
iGMDRD678Tubastatin A1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CTCF