CTCF
Summary: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:604167 Ensembl IDEnsembl:ENSG00000102974 HGNC IDHGNC:HGNC:13723 PHARMGKB IDPA26998 Map Location16q22.1 |
GO terms in CTCF
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
BP | IEA | GO:0006351 | transcription, DNA-templated |
BP | IEA | GO:0007059 | chromosome segregation |
BP | IMP | GO:0008285 | negative regulation of cell proliferation |
BP | IMP | GO:0010628 | positive regulation of gene expression |
BP | IDA | GO:0016584 | nucleosome positioning |
Gene expression in normal tissue: CTCF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTCF
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP3584 | MECP2 and Associated Rett Syndrome |
wikipathways | WP3995 | Prion disease pathway |
wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
biocarta | ctcfpathway | ctcf: first multivalent nuclear factor |
reactome | R-HSA-1266738 | Developmental Biology |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in CTCF
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |