iGMDRD338


Canonical SMILES: C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

InChI: InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+

InChI Key: JLOXTZFYJNCPIS-FYWRMAATSA-N

Loading, please wait...
Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameMEK Inhibitor in EGFR mutant
Pubchem CID9549280
Drug StatusFamily
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

2reactome: Signaling by Receptor Tyrosine Kinases2reactome: Signal Transduction1reactome: Neurotransmitter receptors and postsynaptic signal transmission1reactome: Transmission across Chemical Synapses1wikipathways: Serotonin Receptor 4-6-7 and NR3C Signaling1wikipathways: Serotonin HTR1 Group and FOS Pathway1wikipathways: Estrogen signaling pathway1reactome: Neuronal System1reactome: Spry regulation of FGF signaling1reactome: Prolonged ERK activation events

Drug-gene GO enrichments

3CC: cytosol2BP: MAPK cascade2CC: plasma membrane2MF: protein serine/threonine kinase activity1MF: protein kinase activity1CC: intracellular membrane-bounded organelle1MF: calcium ion binding1MF: identical protein binding1MF: small GTPase binding1MF: ATP binding

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
673 BRAF 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in MEK Inhibitor in EGFR mutant

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​