CBLL1
Summary: This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Cbl proto-oncogene like 1 | MIM:606872 | Ensembl:ENSG00000105879 | HGNC:HGNC:21225 | PA134960329 | 7q22.3 |
GO terms in CBLL1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0007162 | negative regulation of cell adhesion |
| BP | IBA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | TAS | GO:0016567 | protein ubiquitination |
| BP | IBA | GO:0030155 | regulation of cell adhesion |
| BP | ISS | GO:0030335 | positive regulation of cell migration |
| BP | TAS | GO:0035635 | entry of bacterium into host cell |
| BP | ISS | GO:0045807 | positive regulation of endocytosis |
| BP | IMP | GO:0080009 | mRNA methylation |
| BP | IDA | GO:0098609 | cell-cell adhesion |
| CC | IC | GO:0000151 | ubiquitin ligase complex |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0036396 | RNA N6-methyladenosine methyltransferase complex |
| MF | ISS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | TAS | GO:0004842 | ubiquitin-protein transferase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0042802 | identical protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IBA | GO:0061630 | ubiquitin protein ligase activity |
Gene expression in normal tissue: CBLL1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CBLL1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-8876384 | Listeria monocytogenes entry into host cells |
| reactome | R-HSA-8876493 | InlA-mediated entry of Listeria monocytogenes into host cells |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CBLL1
CLASSFICATION
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