CAV2
Summary: The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. This protein may function as a tumor suppressor. This gene and related family member (CAV1) are located next to each other on chromosome 7, and express colocalizing proteins that form a stable hetero-oligomeric complex. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. Additional isoforms resulting from the use of alternate in-frame translation initiation codons have also been described, and shown to have preferential localization in the cell (PMID:11238462). [provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caveolin 2 | MIM:601048 | Ensembl:ENSG00000105971 | HGNC:HGNC:1528 | PA26108 | 7q31.2 |
Gene Categories:
TUMOR SUPPRESSORGO terms in CAV2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0005198 | structural molecule activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0019901 | protein kinase binding |
| MF | IEA | GO:0030674 | protein binding, bridging |
| MF | IBA | GO:0032947 | protein-containing complex scaffold activity |
| MF | IEA | GO:0032947 | protein-containing complex scaffold activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0097110 | scaffold protein binding |
| BP | IBA | GO:0001937 | negative regulation of endothelial cell proliferation |
| BP | ISS | GO:0001937 | negative regulation of endothelial cell proliferation |
| BP | IEA | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IBA | GO:0006869 | lipid transport |
| BP | IDA | GO:0006906 | vesicle fusion |
| BP | ISS | GO:0007005 | mitochondrion organization |
| BP | ISS | GO:0007029 | endoplasmic reticulum organization |
| BP | IEP | GO:0007088 | regulation of mitotic nuclear division |
| BP | IBA | GO:0008286 | insulin receptor signaling pathway |
| BP | IDA | GO:0008286 | insulin receptor signaling pathway |
| BP | IDA | GO:0016050 | vesicle organization |
| BP | IGI | GO:0019065 | receptor-mediated endocytosis of virus by host cell |
| BP | IBA | GO:0030154 | cell differentiation |
| BP | IEA | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IBA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0043547 | positive regulation of GTPase activity |
| BP | IMP | GO:0044791 | positive regulation by host of viral release from host cell |
| BP | IMP | GO:0044794 | positive regulation by host of viral process |
| BP | IDA | GO:0048278 | vesicle docking |
| BP | ISS | GO:0048741 | skeletal muscle fiber development |
| BP | IEA | GO:0051259 | protein complex oligomerization |
| BP | IMP | GO:0060161 | positive regulation of dopamine receptor signaling pathway |
| BP | IBA | GO:0070836 | caveola assembly |
| BP | IDA | GO:0070836 | caveola assembly |
| BP | IMP | GO:0070836 | caveola assembly |
| CC | IEA | GO:0000139 | Golgi membrane |
| CC | IEA | GO:0002080 | acrosomal membrane |
| CC | IDA | GO:0005622 | intracellular |
| CC | IEA | GO:0005634 | nucleus |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005794 | Golgi apparatus |
| CC | ISS | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IBA | GO:0005887 | integral component of plasma membrane |
| CC | IDA | GO:0005887 | integral component of plasma membrane |
| CC | IBA | GO:0005901 | caveola |
| CC | IDA | GO:0005901 | caveola |
| CC | IBA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0030133 | transport vesicle |
| CC | IDA | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane |
| CC | IBA | GO:0031410 | cytoplasmic vesicle |
| CC | IDA | GO:0031410 | cytoplasmic vesicle |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IBA | GO:0042383 | sarcolemma |
| CC | IDA | GO:0045121 | membrane raft |
| CC | IBA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
Gene expression in normal tissue: CAV2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CAV2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| netpath | Pathway_EGFR1 | EGFR1 |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP4148 | Splicing factor NOVA regulated synaptic proteins |
| wikipathways | WP437 | EGF-EGFR Signaling Pathway |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CAV2
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